National Institute on Drug Abuse - Intramural Research Program
Featured Paper of the Month – December 2020
Published in ACS Medicinal Chemistry Letters by Battiti, Francisco O; Newman, Amy Hauck; Bonifazi, Alessandro
In this study, starting from our highly selective and potent D3R agonist 5 , we further investigated the chemical space around the linker portion of the molecule, via insertion of a hydroxyl substituent and ring-expansion of the trans cyclopropyl moiety into a trans -cyclohexyl scaffold…
Hot Off the Press – November 23 , 2020 The Ventral tegmental area (VTA) is best known for containing dopamine neurons that play a role in motivated behavior. However, we had previously demonstrated that the VTA has neurons that co-transmit glutamate and GABA, neurons that transmit glutamate without GABA, and neurons that transmit GABA without… [Read More]
Hot Off the Press – November 23 , 2020 Adaptive decision making requires us to imagine – or mentally simulate – potential outcomes, particularly when potential outcomes are far off, uncertain, or even anecdotal. This ability depends in part on the orbitofrontal cortex (OFC) , an important part of the frontal lobe altered in addiction…. [Read More]
Dr. Zhou is currently a postdoctoral fellow in the lab of Dr. Geoffrey Schoenbaum at the NIDA IRP where he studies neural circuit mechanisms of animal behavior and cognition. Using in vivo electrophysiology as a primary tool, his research attempts to map neural dynamics embedded in the neural population activities to the hidden cognitive variables… [Read More]
Amy Hauck Newman, Ph.D., has been appointed the Scientific Director of the National Institute on Drug Abuse’s (NIDA) Intramural Research Program (IRP) in Baltimore. NIDA is part of the National Institutes of Health (NIH). Dr. Newman has served as NIDA’s IRP Acting Scientific Director for the past two years. She is also Chief of NIDA’s… [Read More]
Hot Off the Press – November 17 , 2020 Bossert et al. used a rat model of opioid agonist maintenance therapy to study the effect of the novel G-protein-biased mu opioid receptor (MOR) agonist TRV130 on relapse oxycodone seeking and taking during abstinence. They showed that TRV130 decreased oxycodone seeking and taking during abstinence in… [Read More]
Hot Off the Press – November 11 , 2020 The role of ventral tegmental area (VTA) in motivated behavior is well established. However, Barbano et al., demonstrated that a subset of VTA neurons, that utilizes glutamate as signaling molecule, mediates innate defensive behaviors, evolutionary selected responses that promote escaping from dangerous situations. Alterations in innate… [Read More]
Featured Paper of the Month – November 2020
Published in ACS Chemical Neuroscience in Yano, Hideaki; Adhikari, Pramisha; Naing, Sett; Hoffman, Alexander F; Baumann, Michael H; Lupica, Carl R; Shi, Lei
The nonmedical (i.e., recreational) misuse of synthetic cannabinoids (SCs) is a worldwide public health problem. When compared to cannabis, the misuse of SCs is associated with a higher incidence of serious adverse effects, suggesting the possible involvement of noncannabinoid sites of action. Here, we find that, unlike the phytocannabinoid Δ9-tetrahydrocannabinol, the indole-moiety containing SCs, AM2201 and JWH-018, act as positive allosteric modulators (PAMs) at the 5-HT1A receptor (5-HT1AR). This suggests that some biological effects of SCs might involve allosteric interactions with 5-HT1ARs…
The Society for Neuroscience (SfN) has named Lorenzo Leggio, M.D., Ph.D. as the 2020 recipient of the Jacob P. Waletzky Award. The award, supported by the Waletzky Award Prize Fund and the Waletzky Family, is given to a young scientist whose independent research has led to significant conceptual and empirical contributions to the understanding of… [Read More]
Reviews To Read – October 2020. Recent advances in animal addiction models have emphasized translational challenges. In this Review, Venniro and colleagues introduce a reverse translational approach that may provide an ecologically relevant platform from which to discover new circuits, test new medications and improve translation.
