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NIDA IRP

National Institute on Drug Abuse - Intramural Research Program

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    • Behavioral Neuroscience Research Branch
    • Integrative Neuroscience Research Branch
    • Translational Addiction Medicine Branch
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    • OECD Awards
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Integrative Neuroscience Research Branch

Marisela Morales, Ph.D.

Marisela Morales, Ph.D.

Branch Chief

Marisela Morales, Ph.D.

Contact

Location:
Biomedical Research Center
251 Bayview Blvd
Suite 200, Room 06A729
Baltimore, MD 21224

Phone: 443-740-2717

Fax : 443-740-2817

Email: MMORALES@intra.nida.nih.gov

Branch Overview

The Integrative Neuroscience Branch conducts research at the cellular, molecular, and systems levels to identify the neural substrates upon which drugs of abuse act to produce long-term alterations in behavior and brain function. The aims of our research are to:

  • Delineate the afferent inputs, efferent targets, physiological characteristics, and behavioral functions of ventral tegmental area and dorsal raphe neurons. In order to accomplish this, we utilize classical tract tracing techniques, radioactive and nonradioactive in situ hybridization, ex vivo electrophysiological recordings, in vivo single-unit electrophysiological recordings, optogenetics, pharmacogenetics, and behavioral assays (Neuronal Networks Section);
  • Identify drug-evoked alterations in sigma receptor function and interorganellar signaling between the endoplasmic reticulum, mitochondrion, and nucleus that lead to abnormalities in neuronal function and structure associated with the chronic use of abused drugs (Cellular Pathobiology Section)
  • Studies the role of endoplasmic reticulum stress and inflammation in neuronal dysfunction caused by substance abuse or neurodegenerative diseases (Molecular Mechanisms of Cellular Stress and Inflammation)

Branch Sections

  • Neuronal Networks Section
  • Cellular Pathobiology Section
  • Behavioral Neuroscience Section
  • Neurobiology of Addiction Section
  • Molecular Mechanisms of Cellular Stress and Inflammation Section
  • Stress and Addiction Neuroscience Unit

Primary Sidebar

Integrative Neuroscience Branch

  • Staff
  • Neuronal Networks Section
  • Cellular Pathobiology Section
  • Neurobiology of Addiction Section
  • Molecular Mechanisms of Cellular Stress and Inflammation Section
  • Stress and Addiction Neuroscience Unit

Organization

  • Organization
  • Faculty
  • Office of the Scientific Director
  • Office of the Clinical Director
  • Administrative Management Branch
  • Molecular Targets and Medications Discovery Branch
  • Cellular and Neurocomputational Systems Branch
  • Molecular Neuropsychiatry Research Branch
  • Neuroimaging Research Branch
  • Behavioral Neuroscience Research Branch
  • Integrative Neuroscience Research Branch
  • Translational Addiction Medicine Branch
  • Core Facilities
  • Women Scientist Advisors
  • Careers at NIDA IRP
  • Technology Development Initiative
  • Diversity and Outreach Training Programs
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