IRP News

2023 NIH Green Labs Program

Congratulations to the NIDA labs who participated and received awards in the 2023 NIH Green Labs Program! Molecular Neuropsychiatry Section, Adjei, Nasser – Gold Translational Analytical Core, Kryszak, Lindsay – Silver Neuronal Circuits and Behavior Section, Sarsfield, Sarah  – Silver Integrative Neuroscience Research Branch, Neuronal Networks Section, Barbano, Flavia – Bronze Molecular Targets and Medications… [Read More]

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Reviews To Read

Modeling methamphetamine use disorder and relapse in animals: Short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain

Reviews To Read – January 2024. Published in Neuroscience & Biobehavioral Reviews by Khalid Elhadi, Atul P. Daiwile, and Jean Lud Cadet of the NIDA IRP Molecular Neuropsychiatry Research Section. Methamphetamine use disorder (MUD) is very widespread in the world because methamphetamine is easy to make and cheap to buy. Heavy users usually take the drug… [Read More]

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Featured Papers

Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone

Featured Paper of the Month – June 2024

Published in Molecular Psychiatry by Marjorie Levinstein and Michael Michaelides, et al. of the NIDA IRP Biobehavioral Imaging and Molecular Neuropsychopharmacology Section.

In this article we performed an in depth in vivo, in vitro, and in silico analysis of (R,S)-methadone and its enantiomers. (S)-methadone is currently in phase III trials as an antidepressant and is frequently referred to as an N-methyl-D-aspartate receptor (NMDAR) antagonist, like ketamine. Here we show that (S)-methadone, like (R)-methadone and (R,S)-methadone is an agonist at the mu opioid receptor (MOR) and does not bind to NMDARs at physiologically relevant concentrations.

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