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IRP News

NIH IRP GLP-1 Workshop

Friday, July 24, 2026 – 8:30 am – 4:15 pm Masur Auditorium – Building 10 NIH Bethesda Campus NIH Videocast Link Here Chairs/Organizers Lorenzo Leggio, M.D., Ph.D., NIDA/NIAAA Mike Krashes, Ph.D., NIDDK Schedule 8:45 – 8:55 Lorenzo Leggio, M.D., Ph.D. (NIDA/NIAAA) and Mike Krashes, Ph.D. (NIDDK) Welcome 8:55 – 9:00 Janice Lee, D.D.S., M.D., M.S., Deputy… [Read More]

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Hot Off the Press

Hippocampal output suppresses orbitofrontal cortex schema cell formation

Hot Off the Press – August 21, 2025 Published in Nature Neuroscience by  Wenhui Zong and Geoffrey Schoenbaum, et al. of the NIDA IRP Behavioral Neurophysiology Neuroscience Section. Summary The orbitofrontal cortex (OFC) and hippocampus (HC) are both thought to contribute to the construction of cognitive maps and their generalization into schemas, yet the nature… [Read More]

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Reviews To Read

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Featured Papers

Chronic delivery of buprenorphine during abstinence decreases incubation of heroin seeking and neuronal activation in medial prefrontal cortex and striatum in male and female rats

Featured Paper of the Month – May 2026
Published in JAMA Network Open by Xiang Xiao and Yihong Yang et al. of the NIDA IRP Magnetic Resonance Imaging and Spectroscopy Section.

Buprenorphine is an FDA-approved medication for opioid addiction, but the brain regions underlying its therapeutic effects are unknown. In this study, we tested whether chronic buprenorphine reduces the time-dependent increase (“incubation”) in heroin seeking during abstinence.

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