IRP News

Kauê Costa named an Allen Institute Next Generation Leader

The Allen Institute has announced six new Next Generation Leaders (NGL), members of a unique neuroscience advisory panel made up of early-career researchers who will help advise research efforts at the Allen Institute for Brain Science, the MindScope Program, and the Allen Institute for Neural Dynamics. Among the new panel members is Kauê Machado Costa,… [Read More]

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Hot Off the Press

Calcium activity is a degraded estimate of spikes

Hot Off the Press – December 22, 2022 Summary Neurons communicate via electrical signals – spikes – and recording these has provided fundamental information regarding how the brain works. When neurons send electrical signals, several other biological signals occur, notably calcium. Calcium signaling is often used to make inferences about spike activity. However, it was… [Read More]

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Reviews To Read

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Featured Papers

Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies

Featured Paper of the Month – February 2023
Published in Molecular Psychiatry with authors from the NIDA IRP Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section and Neurobiology of Addiction Section.

The steroid hormone aldosterone regulates fluid and electrolyte homeostasis mainly via its mineralocorticoid receptor. Previous studies suggest that this pathway may also modulate alcohol seeking and consumption. Spironolactone is a nonselective mineralocorticoid receptor antagonist primarily used in clinical practice to treat cardiovascular conditions. Preliminary evidence indicates that spironolactone may also reduce alcohol use…

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