• Home
  • News
    ▼
    • Featured Paper of the Month
    • Reviews to Read
    • Hot off the Press
    • IRP News
    • Awards
    • Technology Development Initiative Paper of the Month
    • Seminar Schedule
  • About
    ▼
    • About NIDA IRP
    • Contact Us
    • Directions and Map
    • Careers at NIDA IRP
  • Organization
    ▼
    • Faculty
    • Office of the Scientific Director
    • Office of the Clinical Director
    • Office of Education and Career Development
    • Administrative Management Branch
    • Molecular Targets and Medications Discovery Branch
    • Cellular and Neurocomputational Systems Branch
    • Molecular Neuropsychiatry Research Branch
    • Neuroimaging Research Branch
    • Behavioral Neuroscience Research Branch
    • Integrative Neuroscience Research Branch
    • Translational Addiction Medicine Branch
    • Core Facilities
    • Women Scientist Advisors
  • Training Programs
    ▼
    • Office of Education and Career Development
    • OECD Awards
    • Summer Internship Program
    • Postbaccalaureate Program
    • Graduate Partnership Program
    • Postdoctoral Program
    • Diversity and Outreach Training Programs
    • NIDA Speakers Bureau
    • Clinical Electives Program
  • Study Volunteers
  • Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar

NIDA IRP

National Institute on Drug Abuse - Intramural Research Program

  National Institute on Drug Abuse | NIH IRP | Treatment Information
  • Home
  • News
    • Featured Paper of the Month
    • Reviews to Read
    • Hot off the Press
    • IRP News
    • Awards
    • Technology Development Initiative Paper of the Month
    • Seminar Schedule
  • About
    • About NIDA IRP
    • Contact Us
    • Directions and Map
    • Careers at NIDA IRP
  • Organization
    • Faculty
    • Office of the Scientific Director
    • Office of the Clinical Director
    • Office of Education and Career Development
    • Administrative Management Branch
    • Molecular Targets and Medications Discovery Branch
    • Cellular and Neurocomputational Systems Branch
    • Molecular Neuropsychiatry Research Branch
    • Neuroimaging Research Branch
    • Behavioral Neuroscience Research Branch
    • Integrative Neuroscience Research Branch
    • Translational Addiction Medicine Branch
    • Core Facilities
    • Women Scientist Advisors
  • Training Programs
    • Office of Education and Career Development
    • OECD Awards
    • Summer Internship Program
    • Postbaccalaureate Program
    • Graduate Partnership Program
    • Postdoctoral Program
    • Diversity and Outreach Training Programs
    • NIDA Speakers Bureau
    • Clinical Electives Program
  • Study Volunteers

Featured Paper of the Month

Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism

Study authors Hong-Ju Yang and Briana J Hempel

Featured Paper of the Month – August 2022
Published in The Journal of Neuroscience by Hong-Ju Yang, Briana J Hempel, and Zheng-Xiong Xi, et al. of the NIDA IRP Addiction Biology Unit.

It is well known that glutamate plays an important role in relapse to drug seeking. However, the role of glutamate in drug reward is unclear. In this report, we found that elevating extracellular glutamate level in the nucleus accumbens (NAc) by TFB-TBOA, a selective astrocyte glutamate transporter inhibitor, dose-dependently inhibits cocaine self-administration and brain-stimulation reward. Mechanistic assays indicate that prolonged cocaine self-administration selectively upregulates NMDA-GluN2B receptor subtype expression in striatal dopaminoceptive neurons…

Searching for a Signal: Self-Reported Kratom Dose-Effect Relationships Among a Sample of US Adults With Regular Kratom Use Histories

Featured Paper of the Month – July 2022
Published in Frontiers in Pharmacology by Kirsten Smith, Ph.D.; Jeffrey Rogers, BS., B.A.; and David Epstein, Ph.D.; et al. of the NIDA IRP Real-world Assessment, Prediction, and Treatment Unit.

Kratom is a plant increasingly used in the US for the psychoactive properties of the more than four dozen alkaloids it contains. Their mechanisms of action are thought to be opioidergic, adenosinergic, serotoninergic, dopaminergic, and adrenergic. Whole-plant-derived kratom products, almost always taken orally, produce dose-dependent stimulatory and analgesic effects. We know of only one published laboratory study on kratom’s effects in humans; however, surveys have increasingly helped show a complex and changing landscape of kratom use. In this online, nationwide study, we asked 129 people with kratom use histories to report on the effects of their kratom products…

Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors

I portion of a figure from this study

Featured Paper of the Month – June 2022
Published in Neuropsychopharmacology by Zhi-Bing You, Ph.D. and Eliot Gardner, Ph.D., et al. of the NIDA IRP Neuropsychopharmacology Section.

Cocaine addiction is a significant medical and public concern.  Despite decades of research effort, development of anti-addiction, anti-craving, and anti-relapse medications for cocaine addiction remains largely unsuccessful.  To aid this medication development, more knowledge is needed about the brain circuits and mechanisms that underlie addiction.  In the present article, the authors show that: (1) elevation of the brain hormone ghrelin by cocaine plays a critical role in cocaine-taking and in cocaine-seeking behaviors;  (2) acquisition of cocaine-taking behavior is associated with enhancement of the stimulatory effects of cocaine and of cocaine-associated environmental cues on brain ghrelin…

Structure-activity relationships for 5F-MDMB-PICA and its 5F-pentylindole analogs to induce cannabinoid-like effects in mice

Grant Glatfelter, Ph.D.

Featured Paper of the Month – May 2022
Published in Neuropsychopharmacology by Grant Glatfelter, John Partilla and Michael Baumann of the NIDA IRP Designer Drug Research Unit.

5F-MDMB-PICA is a potent synthetic cannabinoid associated with public harm from recreational use. Little is known about the pharmacology of 5F-MDMB-PICA underlying it’s potent effects. This study examined the pharmacological effects of 5F-MDMB-PICA at cannabinoid type 1 receptors (CB1) in mice relative to several structurally related compounds. Results show that certain structural features of the “head” groups of 5F-MDMB-PICA and related compounds dramatically impacts their potencies for CB1 mediated pharmacological effects and for producing cannabinoid-like effects in mice, which is predictive of potency of these compounds in humans…

Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors

Featured Paper of the Month – April 2022
Published in Cell Reports by Justin Siemian and Yeka Aponte, et al. of the NIDA IRP Neuronal Circuits and Behavior Unit.

The lateral hypothalamus (LH) has long been known for its involvement in feeding behaviors. Specifically, GABAergic LH (LHVGAT) neurons are known to mediate food intake (consummatory) and food-seeking (appetitive) behaviors, but GABAergic neurons comprise a large population of neurons that can further be divided into genetically identified subpopulations. Therefore, we sought to determine the function of a subset of LHVGAT neurons identified as leptin receptor-expressing neurons (LHLEPR neurons). We used a combination of neuronal ablation, optogenetics, chemogenetics, and in vivo calcium imaging to study the contributions of LHLEPR neurons to the greater LHVGAT population in mice…

Laterality Hotspots in the Striatum

A portion of a figure from this article

Featured Paper of the Month – March 2022
Published in Cerebral Cortex by Thomas Ross and Elliot Stein of the NIDA IRP Cognitive and Affective Neuroscience of Addiction Section.

The right and left hemispheres of the brain each play a dominant role in certain functions, such as inhibitory control (right) and language (left). Differences in the structure and connections of the right and left hemispheres (i.e., “lateralities”) help to facilitate these functional specialties. Yet, in several neurodevelopment and neuropsychiatric disorders – including addiction – these hemispheric lateralities appear to be abnormal. In this paper, NIDA scientists provide a normative description of laterality in the circuits that connect the frontal cortex to the striatum – a system centrally implicated in addiction…

Gut microbiome and metabolome in a non-human primate model of chronic excessive alcohol drinking.

Study Author Daria Piacentino, M.D., Ph.D., M.Sc.

Featured Paper of the Month – February 2022
Published in Translational Psychiatry by Daria Piacentino and Lorenzo Leggio, et al. of the NIDA IRP Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section.

Chronic excessive alcohol drinking causes more than 80,000 deaths in the U.S. each year. The gut microbiota, which hosts more than a trillion bacteria, is gaining increasing attention as a potential modulator in neuropsychiatric disorders. Its diversity is fundamental in maintaining homeostasis. There is limited research on the role of the microbiome-gut-brain axis in alcohol use disorder. Dr. Daria Piacentino and her colleagues address the fundamental question on whether chronic excessive alcohol drinking affects the gut microbiome and metabolome in a baboon model, investigated under rigorous controlled experimental conditions…

Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior

Juan Gomez, Ph.D.

Featured Paper of the Month – January 2022
Published in Translational Psychiatry by Juan Gomez and Michael Michaelides of the NIDA IRP Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit.

Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc also binds to the DAT, but the in vivo relevance of this interaction is unknown. We examined this interaction by altering zinc availability and measuring behavior and physiology associated with cocaine exposure. To alter zinc levels, we manipulated dietary zinc or used a mouse model that lacked the zinc transporter ZnT3. The body has no storage system for zinc and one must consistently replenish this essential element via zinc-rich food sources. Of the 24 transporters dedicated to moving zinc around the body, ZnT3 is necessary to shuttle zinc around the brain…

Hypothalamic control of interoceptive hunger

Study authors Justin Siemian and Sarah Sarsfield

Featured Paper of the Month – December 2021
Published in Current Biology by Justin Siemian, Sarah Sarsfield, Yeka Aponte of the NIDA IRP Neuronal Circuits and Behavior Unit.

Regulating food intake is essential for survival and many factors influence feeding behaviors beyond caloric need or “hunger”. Despite this, some neurons that drive feeding in mice are routinely referred to as ‘‘hunger neurons,’ whereas others are not. To understand how specific hypothalamic neurons control interoceptive hunger, we trained mice to discriminate feelings of “hunger” from satiety. We then used optogenetics to manipulate the activity of three hypothalamic neuronal populations with well-known effects on feeding while mice performed this behavioral task…

Functional connectivity of dorsolateral prefrontal cortex predicts cocaine relapse: implications for neuromodulation treatment

A portion of a figure from this study

Featured Paper of the Month – November 2021
Published in Brain Communications by Tianye Zhai and Yihong Yang et al. in the NIDA IRP Magnetic Resonance Imaging and Spectroscopy Section.

Cocaine use disorder is a highly relapsing chronic brain disease with current treatments relatively ineffective. Finding brain areas and brain functional circuits that are relevant to cocaine relapse is crucial in understanding the brain mechanisms of addiction as well as in developing effective treatment protocols. By combining the resting-state fMRI and the Cox regression based predictive modeling, Zhai et al. identified three sets of dorsolateral prefrontal cortex (dlPFC)-centric functional circuits that predict cocaine relapse with high accuracy, provide insights into the multiple roles ofthe dlPFC in brain functioning that affect treatment outcome, and suggest these dlPFC loci as potential neuromodulation targets for addiction treatment…

  • « Go to Previous Page
  • Go to page 1
  • Go to page 2
  • Go to page 3
  • Go to page 4
  • Interim pages omitted …
  • Go to page 11
  • Go to Next Page »

Primary Sidebar

News

  • All News and Featured Publications
  • Featured Paper of the Month
  • Hot off the Press
  • Reviews to Read
  • IRP News
  • Awards
  • Technology Development Initiative Paper of the Month
  • Seminar Schedule
Home / Archives for News Main / Featured Paper of the Month
  • National Institute on Drug Abuse
  • NIH Intramural Research Program
  • National Institutes of Health
  • Health and Human Services
  • USA.GOV
  • Treatment Information
  • Contact Us
  • Careers at NIDA IRP
  • Accessibility
  • Privacy
  • HHS Vulnerability Disclosure
  • Freedom of Information Act
  • Document Viewing Tools
  • Offsite Links
  • National Institute on Drug Abuse
  • NIH Intramural Research Program
  • National Institutes of Health
  • Health and Human Services
  • USA.GOV
  • Treatment Information
  • Contact Us
  • Careers at NIDA IRP
  • Accessibility
  • Privacy
  • HHS Vulnerability Disclosure
  • Freedom of Information Act
  • Document Viewing Tools
  • Offsite Links