Reviews To Read – January 2023.
Published in Basic & Clinical Pharmacology & Toxicology by Gisela Andrea Camacho-Hernandez , Khorshada Jahan, and Amy Hauck Newman of the NIDA IRP Medicinal Chemistry Section.
The monoamine transporters are proteins that are primarily responsible for the clearance of dopamine, serotonin and norepinephrine, important monoamine neurotransmitters that are involved in key physiological processes. Advancement in our understanding of how these transporters operate in health and disease has been central for the search of medications to treat several neuropsychiatric disorders including, psychostimulant (e.g., cocaine, methamphetamine) use disorders. Fluorescently labeled ligands (FLL) are chemical tools that have been utilized to visualize proteins in living cells. Herein, we describe the design and important characteristics of monoamine transporter-directed FLLs. We highlight the advantages and limitations on how they have been employed as well as future development and potential applications.
Illuminating the monoamine transporters: Fluorescently labelled ligands to study dopamine, serotonin and norepinephrine transporters Journal Article
In: Basic Clin Pharmacol Toxicol, 2022, ISSN: 1742-7843.