Hot Off the Press! – April 2016
Cadet, J L; Brannock, C; Krasnova, I N; Jayanthi, S; Ladenheim, B; McCoy, M T; Walther, D; Godino, A; Pirooznia, M; Lee, R S
Mol Psychiatry, 22 (8), pp. 1196–1204, 2016, ISSN: 1476-5578 (Electronic); 1359-4184 (Linking).
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The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys
Featured Paper of the Month – April 2016
Published in Biological Psychiatry by Justinova, Zuzana; Panlilio, Leigh V; Secci, Maria E; Redhi, Godfrey H; Schindler, Charles W; Cross, Alan J; Mrzljak, Ladislav; Medd, Amy; Shaham, Yavin; Goldberg, Steven R
Based on rodent studies, group II metabotropic glutamate receptors (mGluR2 and mGluR3) were suggested as targets for addiction treatment. However, LY379268 and other group II agonists do not discriminate between the mainly presynaptic inhibitory mGluR2 (the proposed treatment target) and mGluR3. These agonists also produce tolerance over repeated administration and are no longer considered for addiction treatment…
VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons
Hot Off the Press! – March 2016
Qi, Jia; Zhang, Shiliang; Wang, Hui-Ling; Barker, David J; Miranda-Barrientos, Jorge; Morales, Marisela
Nat Neurosci, 19 (5), pp. 725–733, 2016, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).
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The nutrient sensor OGT in PVN neurons regulates feeding
Hot Off the Press! – March 2016
Lagerlöf, Olof; Slocomb, Julia E; Hong, Ingie; Aponte, Yeka; Blackshaw, Seth; Hart, Gerald W; Huganir, Richard L
Science, 351 (6279), pp. 1293–1296, 2016, ISSN: 1095-9203 (Electronic); 0036-8075 (Linking).
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Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice
Hot Off the Press! – March 2016
Xue, Xue; Yang, Jing-Yu; He, Yi; Wang, Li-Rong; Liu, Ping; Yu, Li-Sha; Bi, Guo-Hua; Zhu, Ming-Ming; Liu, Yue-Yang; Xiang, Rong-Wu; Yang, Xiao-Ting; Fan, Xin-Yu; Wang, Xiao-Min; Qi, Jia; Zhang, Hong-Jie; Wei, Tuo; Cui, Wei; Ge, Guang-Lu; Xi, Zheng-Xiong; Wu, Chun-Fu; Liang, Xing-Jie
Nat Nanotechnol, 11 (7), pp. 613–620, 2016, ISSN: 1748-3395 (Electronic); 1748-3387 (Linking).
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Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model
Featured Paper of the Month – March 2016
Published in Biological Psychiatry by Caprioli, Daniele; Venniro, Marco; Zeric, Tamara; Li, Xuan; Adhikary, Sweta; Madangopal, Rajtarun; Marchant, Nathan J; Lucantonio, Federica; Schoenbaum, Geoffrey; Bossert, Jennifer M; Shaham, Yavin
Cue-induced methamphetamine craving increases after prolonged forced (experimenter-imposed) abstinence from the drug (incubation of methamphetamine craving). Here, we determined whether this incubation phenomenon would occur under conditions that promote voluntary (self-imposed) abstinence…
Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area
Featured Paper of the Month – February 2016
Published in Cell Reports by Wang, Huikun; Treadway, Tyler; Covey, Daniel P; Cheer, Joseph F; Lupica, Carl R
Cocaine is a highly addictive drug that acts upon the brain’s reward circuitry via the inhibition of monoamine uptake. Endogenous cannabinoids (eCB) are lipid molecules released from midbrain dopamine (DA) neurons that modulate cocaine’s effects through poorly understood mechanisms…
High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice
Featured Paper of the Month – January 2016
Published in The Journal of Medical Chemistry by Boateng, Comfort A; Bakare, Oluyomi M; Zhan, Jia; Banala, Ashwini K; Burzynski, Caitlin; Pommier, Elie; Keck, Thomas M; Donthamsetti, Prashant; Javitch, Jonathan A; Rais, Rana; Slusher, Barbara S; Xi, Zheng-Xiong; Newman, Amy Hauck
The dopamine D3 receptor (D3R) is a promising target for the development of pharmacotherapeutics to treat substance use disorders. Several D3R-selective antagonists are effective in animal models of drug abuse, especially in models of relapse. Nevertheless, poor bioavailability, metabolic instability, and/or predicted toxicity have impeded success in translating these drug candidates to clinical use…
Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors
Hot Off the Press! – December 2015
Chang, Chun Yun; Esber, Guillem R; Marrero-Garcia, Yasmin; Yau, Hau-Jie; Bonci, Antonello; Schoenbaum, Geoffrey
Nat Neurosci, 19 (1), pp. 111–116, 2016, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).
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Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.
Featured Paper of the Month – December 2015
Published in The Journal of Medical Chemistry by Selfridge, Brandon R; Wang, Xiaohui; Zhang, Yingning; Yin, Hang; Grace, Peter M; Watkins, Linda R; Jacobson, Arthur E; Rice, Kenner C
Activation of Toll-like receptors has been linked to neuropathic pain and opioid dependence. (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been shown to reverse neuropathic pain in rat studies. We designed and synthesized compounds based on (+)-naltrexone and (+)-noroxymorphone and evaluated their TLR4 antagonist activities by their effects on inhibiting lipopolysaccharide (LPS) induced TLR4 downstream nitric oxide (NO) production in microglia BV-2 cells…
