May 2017 Congratulations to Da-Ting Lin for winning a 2016 Health and Human Services (HHS) Green Champion Award! Dr. Da-Ting Lin has won this year’s award for Sustainable Acquisitions – Individual. Dr. Lin has worked diligently as an Investigator to integrate sustainable practices into his research using in vivo optical imaging methods. He has prioritized energy… [Read More]
News Main
Barry J. Hoffer awarded Honorary Doctors at the University of Helsinki
May 2017 Dr. Barry J. Hoffer, the former Scientific Director of the NIDA IRP, has been awarded an Honorary Doctors of the Faculty of Philosophy from the University of Helsinki for his lifelong work in neuropharmacology. The Faculty of Philosophy of the University of Helsinki confers distinguished persons from the fields of science, culture and… [Read More]
Dopamine transients are sufficient and necessary for acquisition of model-based associations.
Hot Off The Press – April 2017
Sharpe, Melissa J; Chang, Chun Yun; Liu, Melissa A; Batchelor, Hannah M; Mueller, Lauren E; Jones, Joshua L; Niv, Yael; Schoenbaum, Geoffrey
Nat Neurosci, 20 (5), pp. 735–742, 2017, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).
[Read More]
Role of Dorsomedial Striatum Neuronal Ensembles in Incubation of Methamphetamine Craving after Voluntary Abstinence
Featured Paper of the Month – April 2017
Published in The Journal of Neuroscience by Caprioli, Daniele; Venniro, Marco; Zhang, Michelle; Bossert, Jennifer M; Warren, Brandon L; Hope, Bruce T; Shaham, Yavin
We recently developed a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this incubation. We trained rats to self-administer palatable food pellets (6 d, 6 h/d) and methamphetamine (12 d, 6 h/d)…
Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior.
Hot Off the Press! – March 2017
Edwards, Nicholas J; Tejeda, Hugo A; Pignatelli, Marco; Zhang, Shiliang; McDevitt, Ross A; Wu, Jocelyn; Bass, Caroline E; Bettler, Bernhard; Morales, Marisela; Bonci, Antonello
Nat Neurosci, 20 (3), pp. 438–448, 2017, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).
[Read More]
Key role of the dopamine D4 receptor in the modulation of corticostriatal glutamatergic neurotransmission.
Featured Paper of the Month – March 2017
Published in Science Advances by Bonaventura, Jordi; Quiroz, Cesar; Cai, Ning-Sheng; Rubinstein, Marcelo; Tanda, Gianluigi; Ferre, Sergi
Polymorphic variants of the dopamine D4 receptor gene (DRD4) have been repeatedly associated with numerous neuropsychiatric disorders. Yet, the functional role of the D4 receptor and the functional differences of the products of DRD4 polymorphic variants remained enigmatic…
CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers.
Featured Paper of the Month – February 2017
Published in Biological Psychiatry by Li, Sufang; Yang, Yihong; Hoffmann, Ewa; Tyndale, Rachel F; Stein, Elliot A
Variation in the CYP2A6 gene alters the rate of nicotine metabolic inactivation and is associated with smoking behaviors and cessation success rates. The underlying neurobiological mechanisms of this genetic influence are unknown…
Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning.
Hot Off the Press! – January 2017
Barbera, Giovanni; Liang, Bo; Zhang, Lifeng; Gerfen, Charles R; Culurciello, Eugenio; Chen, Rong; Li, Yun; Lin, Da-Ting
Neuron, 92 (1), pp. 202–213, 2016, ISSN: 1097-4199 (Electronic); 0896-6273 (Linking).
[Read More]
Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity.
Hot Off the Press! – January 2017
Tejeda, Hugo A; Wu, Jocelyn; Kornspun, Alana R; Pignatelli, Marco; Kashtelyan, Vadim; Krashes, Michael J; Lowell, Brad B; Carlezon, William Jr A; Bonci, Antonello
Nat Neurosci, 20 (3), pp. 438–448, 2017, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).
[Read More]
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems.
Reviews To Read – January 2017
Su, Tsung-Ping; Su, Tzu-Chieh; Nakamura, Yoki; Tsai, Shang-Yi
Trends Pharmacol Sci, 37 (4), pp. 262–278, 2016, ISSN: 1873-3735 (Electronic); 0165-6147 (Linking).
[Read More]
