Hot Off the Press! – July 2016
Takahashi, Yuji K; Langdon, Angela J; Niv, Yael; Schoenbaum, Geoffrey
Neuron, 91 (1), pp. 182–193, 2016, ISBN: 0896-6273.
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Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders
Featured Paper of the Month – July 2016
Published in Natural Neuroscience by Zhang, Wen; Zhang, Lifeng; Liang, Bo; Schroeder, David; Zhang, Zhong-Wei; Cox, Gregory A; Li, Yun; Lin, Da-Ting
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown. Using TDP-43(A315T) mice, an ALS and FTD model with marked cortical pathology, we found that hyperactive somatostatin interneurons disinhibited layer 5 pyramidal neurons (L5-PNs) and contributed to their excitotoxicity…
Local Control of Extracellular Dopamine Levels in the Medial Nucleus Accumbens by a Glutamatergic Projection from the Infralimbic Cortex
Featured Paper of the Month – June 2016
Published in The Journal of Neuroscience by Quiroz, Cesar; Orru, Marco; Rea, William; Ciudad-Roberts, Andres; Yepes, Gabriel; Britt, Jonathan P; Ferre, Sergi
It is generally assumed that infralimbic cortex (ILC) and prelimbic cortex, two adjacent areas of the medial prefrontal cortex (mPFC) in rodents, provide selective excitatory glutamatergic inputs to the nucleus accumbens (NAc) shell and core, respectively…
Neural estimates of imagined outcomes in the orbitofrontal cortex drive behavior and learning
Featured Paper of the Month – May 2016
Published in Neuron by Takahashi, Yuji K; Chang, Chun Yun; Lucantonio, Federica; Haney, Richard Z; Berg, Benjamin A; Yau, Hau-Jie; Bonci, Antonello; Schoenbaum, Geoffrey
Imagination, defined as the ability to interpret reality in ways that diverge from past experience, is fundamental to adaptive behavior. This can be seen at a simple level in our capacity to predict novel outcomes in new situations. The ability to anticipate outcomes never before received can also influence learning if those imagined outcomes are not received…
Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence
Hot Off the Press! – April 2016
Cadet, J L; Brannock, C; Krasnova, I N; Jayanthi, S; Ladenheim, B; McCoy, M T; Walther, D; Godino, A; Pirooznia, M; Lee, R S
Mol Psychiatry, 22 (8), pp. 1196–1204, 2016, ISSN: 1476-5578 (Electronic); 1359-4184 (Linking).
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The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys
Featured Paper of the Month – April 2016
Published in Biological Psychiatry by Justinova, Zuzana; Panlilio, Leigh V; Secci, Maria E; Redhi, Godfrey H; Schindler, Charles W; Cross, Alan J; Mrzljak, Ladislav; Medd, Amy; Shaham, Yavin; Goldberg, Steven R
Based on rodent studies, group II metabotropic glutamate receptors (mGluR2 and mGluR3) were suggested as targets for addiction treatment. However, LY379268 and other group II agonists do not discriminate between the mainly presynaptic inhibitory mGluR2 (the proposed treatment target) and mGluR3. These agonists also produce tolerance over repeated administration and are no longer considered for addiction treatment…
VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons
Hot Off the Press! – March 2016
Qi, Jia; Zhang, Shiliang; Wang, Hui-Ling; Barker, David J; Miranda-Barrientos, Jorge; Morales, Marisela
Nat Neurosci, 19 (5), pp. 725–733, 2016, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).
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The nutrient sensor OGT in PVN neurons regulates feeding
Hot Off the Press! – March 2016
Lagerlöf, Olof; Slocomb, Julia E; Hong, Ingie; Aponte, Yeka; Blackshaw, Seth; Hart, Gerald W; Huganir, Richard L
Science, 351 (6279), pp. 1293–1296, 2016, ISSN: 1095-9203 (Electronic); 0036-8075 (Linking).
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Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice
Hot Off the Press! – March 2016
Xue, Xue; Yang, Jing-Yu; He, Yi; Wang, Li-Rong; Liu, Ping; Yu, Li-Sha; Bi, Guo-Hua; Zhu, Ming-Ming; Liu, Yue-Yang; Xiang, Rong-Wu; Yang, Xiao-Ting; Fan, Xin-Yu; Wang, Xiao-Min; Qi, Jia; Zhang, Hong-Jie; Wei, Tuo; Cui, Wei; Ge, Guang-Lu; Xi, Zheng-Xiong; Wu, Chun-Fu; Liang, Xing-Jie
Nat Nanotechnol, 11 (7), pp. 613–620, 2016, ISSN: 1748-3395 (Electronic); 1748-3387 (Linking).
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Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model
Featured Paper of the Month – March 2016
Published in Biological Psychiatry by Caprioli, Daniele; Venniro, Marco; Zeric, Tamara; Li, Xuan; Adhikary, Sweta; Madangopal, Rajtarun; Marchant, Nathan J; Lucantonio, Federica; Schoenbaum, Geoffrey; Bossert, Jennifer M; Shaham, Yavin
Cue-induced methamphetamine craving increases after prolonged forced (experimenter-imposed) abstinence from the drug (incubation of methamphetamine craving). Here, we determined whether this incubation phenomenon would occur under conditions that promote voluntary (self-imposed) abstinence…
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