Lorenzo Leggio, M.D., Ph.D. is a 2023 recipient of the Arthur S. Flemming Award for his exceptional service as a Federal Employee. Dr. Leggio received his award in a ceremony on November 14, 2024. The Flemming Awards are managed by the George Washington University’s Trachtenberg School of Public Policy and recipients include many notable figures… [Read More]
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Technology Development Initiative – Paper of the Month – November 2024
DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity Nat Methods.
Understanding how specific brain cells drive behavior requires targeted, cell- and circuit-specific neuropharmacology. DART.2 (Drugs Acutely Restricted by Tethering, version 2) offers improved cellular precision for targeting drugs compared to the original DART.1 technology, enabling unprecedented brain-wide drug distribution and bidirectional modulation of neurotransmitter pathways to examine behavior.
VTA glutamatergic projections to the nucleus accumbens suppress psychostimulant-seeking behavior.
Featured Paper of the Month – November 2024
Published in Neuropsychopharmacology by Flavia Barbano and Marisela Morales, et al. of the NIDA IRP Neuronal Networks Section.
Our study shows that activating a parallel VTA-originating glutamatergic pathway targeting the NAc shell can suppress psychostimulant-seeking behavior.
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site.
Hot Off the Press – October 15, 2024 Published in Nature Communications with contributions from Alessandro Bonifazi , Francisco Battiti and Amy Hauck Newman of the NIDA IRP Medicinal Chemistry Section. Summary We have been designing bitopic ligands for more than two decades with the idea that the secondary pharmacophore would bind in a site… [Read More]
Technology Development Initiative – Paper of the Month – October 2024
High Spatiotemporal Resolution Radial Encoding Single-Vessel fMRI Adv Sci (Weinh)
This paper implemented a radial encoding MRI scheme to measure blood oxygenation level dependent (BOLD) signals of single vessels at microscopic level in the rat somatosensory cortex. In addition, besides from detecting refined hemodynamic response of intracortical micro-venules, this radial encoding-based single-vessel fMRI is capable of distinguishing contributions of intravascular and extravascular effects of signals from vessel and peri-vessel voxels. This combination further benefits real-time single-vessel BOLD fMRI, CBV, and cerebral blood flow studies, making it a valuable tool for advanced brain functional mapping with high-field MRI scanners.
Involvement of dopamine D3 receptor in impulsive choice decision-making in male rats.
Featured Paper of the Month – October 2024
Published in Neuropharmacology by Hui Shen, Zilu Ma and Yihong Yang, et al. of the NIDA IRP Magnetic Resonance Imaging and Spectroscopy Section.
In this study, we used the delay-discounting task (DDT) to identify rats with different levels of impulsivity.
Technology Development Initiative – Paper of the Month – September 2024
Topographical memory analyzed in mice using the Hamlet test, a novel complex maze Neurobiol Learn Mem
This manuscript presents a novel behavioral test relying on a new device and specific paradigm: the Hamlet test. The Hamlet test measures topographic memory and establishes a disorientation index using a paradigm based on spontaneous exploration bypassing common issues with spatial behavioral tests, such as procedural routines and systemic avoidance behavior.
Controversies in Assessment, Diagnosis, and Treatment of Kratom Use Disorder.
Reviews To Read – August 2024. Published in Current Psychiatry Reports by Kirsten Smith, David Epstein & Stephanie Weiss of the NIDA IRP Translational Addiction Medicine Branch. This publication arose because Dr. Weiss was asked to write about “kratom misuse” for a kratom-focused issue of Current Psychiatry Reports. She agreed to contribute, but with a change… [Read More]
Basal forebrain-lateral habenula inputs and control of impulsive behavior.
Hot Off the Press – August 27, 2024 Published in Neuropsychopharmacology by Eun-Kyung Hwang, Agustin Zapata and Carl Lupica, et al. from the NIDA IRP Electrophysiology Research Section. Summary Impulsive behavior is both a predictor and a consequence of drug use and substance use disorders, as well as a symptom of other neuropsychiatric illnesses such… [Read More]
Technology Development Initiative – Paper of the Month – August 2024
A Wearable Device Towards Automatic Detection and Treatment of Opioid Overdose IEEE Trans Biomed Circuits Syst
A wearable closed-loop drug delivery system capable of detecting a hypoxia event and an automatic rapid delivery of a naloxone dose has the potential to mitigate the effects of the opioid epidemic. The closed-loop system can be complementary to the existing evidence-based harm reduction strategies, particularly in instances of unwitnessed overdose where there are no bystanders to administer Narcan.
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