Featured Paper of the Month – October 2022 Published in Proceedings of the Eighth Workshop on Computational Linguistics and Clinical Psychology by Salvatore Giorgi and Brenda Curtis, et al. of the NIDA IRP Technology and Translational Research Unit. Summary Nonsuicidal self-injury (NSSI), or the deliberate injuring of one’s body without intending to die, has been shown… [Read More]
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Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding
Reviews To Read – September 2022. Published in Nature Metabolism and coauthored by Ana Pamela Miranda Tapia and Yeka Aponte of the Neuronal Circuits and Behavior Section (NIDA IRP) and Ivan C. Alcantara and Michael J. Krashes of the Section on Motivational Processes Underlying Appetite (NIDDK IRP). For decades, the prevalence of obesity has surged due… [Read More]
Technology Development Initiative – Paper of the Month – September 2022
SMART: An Open-Source Extension of WholeBrain for Intact Mouse Brain Registration and Segmentation Published in eNeuro. Authors Michelle Jin, Joseph D Nguyen, Sophia J Weber, Carlos A Mejias-Aponte, Rajtarun Madangopal, Sam A Golden Paper presented by Dr. Katherine Savell and selected by the NIDA TDI Paper of the Month Committee. Background and Technological Advancement Whole-brain… [Read More]
Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search
Featured Paper of the Month – September 2022 Published in Molecular Psychiatry by Jordi Bonaventura and Michael Michaelides, et al. of the NIDA IRP Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit. Summary The use of racemic ketamine and the FDA approval of (S)-ketamine are promising developments for the treatment of depression. Nevertheless, racemic ketamine and (S)-ketamine… [Read More]
Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers
Hot Off the Press – August 15, 2022 Summary Communication between brain cells (neurons) generally involves the unidirectional flow of information. Input from upstream cells arrives onto the dendrites, gets processed in the cell body where it is converted into a rapid electrical wave (action potential) that travels down the axon to trigger the release… [Read More]
Technology Development Initiative – Paper of the Month – August 2022
An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid Published in Nature Biomedical Engineering. Authors Farshad Tehrani, Hazhir Teymourian, Brian Wuerstle, Jonathan Kavner, Ravi Patel, Allison Furmidge, Reza Aghavali, Hamed Hosseini-Toudeshki, Christopher Brown, Fangyu Zhang, Kuldeep Mahato, Zhengxing Li, Abbas Barfidokht, Lu Yin, Paul Warren, Nickey Huang, Zina Patel,… [Read More]
Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism
Featured Paper of the Month – August 2022 Published in The Journal of Neuroscience by Hong-Ju Yang, Briana J Hempel and Zheng-Xiong Xi, et al. of the NIDA IRP Addiction Biology Unit. Summary It is well known that glutamate plays an important role in relapse to drug seeking. However, the role of glutamate in drug… [Read More]
Preferential Gs protein coupling of the galanin Gal1 receptor in the µ-opioid-Gal1 receptor heterotetramer
Hot Off the Press – July 8, 2022 Published in Pharmacological Research by Paulo De Oliveira, Ph.D. and Sergi Ferré, M.D., Ph.D. of the NIDA-IRP Integrative Neurobiology Section. Summary We recently demonstrated that complexes (heteromers) of μ-opioid receptors (MORs) and receptors for the neuropeptide galanin of the Gal1subtype (Gal1Rs) localized in the brainstem (in the… [Read More]
Technology Development Initiative – Paper of the Month – July 2022
Verification of technical characteristics and performance of VeinViewer Flex, ICEN IN-G090-2 and AccuVein AV400 transillumination devices Published in Clinica Chimica Acta. Authors Adrijana Dorotić, Ivona Kuktić, Dora Vuljanić, Ana-Maria Šimundić Paper presented by Dr. Kathleen Trychta and selected by the NIDA TDI Paper of the Month Committee Publication Brief Description Background: Venous blood sampling and… [Read More]
Searching for a Signal: Self-Reported Kratom Dose-Effect Relationships Among a Sample of US Adults With Regular Kratom Use Histories
Featured Paper of the Month – July 2022 Published in Frontiers in Pharmacology by Kirsten Smith, Ph.D.; Jeffrey Rogers, BS., B.A.; and David Epstein, Ph.D.; et al. of the NIDA IRP Real-world Assessment, Prediction, and Treatment Unit. Summary Kratom is a plant increasingly used in the US for the psychoactive properties of the more than four dozen alkaloids… [Read More]
