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National Institute on Drug Abuse - Intramural Research Program

  National Institute on Drug Abuse | NIH IRP | Treatment Information
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    • Featured Paper of the Month
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    • About NIDA IRP
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Featured Paper of the Month

Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals.

Study Authors Lorenzo Leggio, Mehdi Farokhnia, Mary Lee and Lisa Farinelli

Featured Paper of the Month – March 2018.

Understanding the neurobiological substrates of excessive alcohol consumption may substantially facilitate efforts to develop better treatments. The cross-talk between the gastrointestinal and central nervous systems, often referred to as the gut–brain axis, is a promising yet underexplored domain in this regard.  Ghrelin is a hormone primarily produced by the stomach and known for its role in increasing appetite and food intake (the “hunger hormone”)…

Bidirectional Modulation of Intrinsic Excitability in Rat Prelimbic Cortex Neuronal Ensembles and Non-Ensembles after Operant Learning

Study Author Leslie Whitaker

Featured Paper of the Month – February 2018.

Learned associations between environmental stimuli and rewards drive learning and motivated behavior. These memories are thought to be encoded by alterations within specific patterns of sparsely distributed neurons called neuronal ensembles that are selectively activated by reward-predictive stimuli. Here we use the Fos promoter to identify strongly activated neuronal ensembles in rat prelimbic cortex (PLC) and assess altered intrinsic excitability following 10 days of operant food self-administration training. First, we selectively ablated Fos-expressing PLC neurons that were active during food self-administration…

High fat diet disrupts endoplasmic reticulum calcium homeostasis in the rat liver.

Study Authors Susanne Bäck, Emily Wires and Kathleen Trychta.

Featured Paper of the Month – January 2018.

From the NIDA IRP Molecular Mechanisms of Cellular Stress and Inflammation Section

The endoplasmic reticulum (ER) is cellular organelle that performs critical functions such as the production and processing of proteins, lipids and drugs.  The ER also serves as the primary storage site for calcium inside the cell.  Using a novel biological sensor protein called GLuc-SERCaMP developed by our laboratory at the NIDA IRP, we show that high fat diets causes changes to ER calcium in the livers of rats.  Unrestricted access to high fat food pellets caused molecular changes to regulators of ER calcium and an increase in markers of fatty liver disease…

Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.

A figure from this article.

Featured Paper of the Month – December 2017.

The etiology and pathophysiology of drug addiction are still not well understood. In this research paper, we show that genetic deletion of mGluR2, a presynaptic glutamate autoreceptor, decreases sensitivity to cocaine reward that causes a compensatory increase in cocaine intake and a decrease in relapse to cocaine-seeking behavior in rats…

A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans.

A figure from this study

Featured Paper of the Month – November 2017

This paper describes three separate studies, conducted with non-human primates, rats, and humans, that investigated the potential contribution of the hormone aldosterone and its mineralocorticoid receptor to alcohol use disorder. Taken together, these findings suggest a relationship between excessive alcohol use, alcohol use disorder, and specific changes in the aldosterone/ mineralocorticoid receptor pathway marked by increased circulating aldosterone and decreased mineralocorticoid receptor gene expression in the amygdala…

Compulsive Addiction-like Aggressive Behavior in Mice.

Study authors Sam Golden and Conor Heins.

Featured Paper of the Month – October 2017
Golden, Sam A; Heins, Conor; Venniro, Marco; Caprioli, Daniele; Zhang, Michelle; Epstein, David H; Shaham, Yavin
Biol Psychiatry, 82 (4), pp. 239–248, 2017, ISSN: 1873-2402 (Electronic); 0006-3223 (Linking)
[Read More]

Salience and default mode network dysregulation in chronic cocaine users predict treatment outcome.

A figure from this study

Featured Paper of the Month – September 2017
Geng, Xiujuan; Hu, Yuzheng; Gu, Hong; Salmeron, Betty Jo; Adinoff, Bryon; Stein, Elliot A; Yang, Yihong
Brain, 140 (5), pp. 1513–1524, 2017, ISSN: 1460-2156 (Electronic); 0006-8950 (Linking).
[Read More]

The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic.

Study authors Haiying Zhang, Zheng-Xiong Xi, and Guohua Bi.

Featured Paper of the Month – August 2017
Zhang, Hai-Ying; Bi, Guo-Hua; Yang, Hong-Ju; He, Yi; Xue, Gilbert; Cao, Jiajing; Tanda, Gianluigi; Gardner, Eliot L; Newman, Amy Hauck; Xi, Zheng-Xiong
Neuropsychopharmacology, 42 (9), pp. 1871–1883, 2017, ISSN: 1740-634X (Electronic); 0893-133X (Linking).
[Read More]

Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R).

Study Authors Vikek Kumar and Amy Moritz.

Featured Paper of the Month – July 2017
Kumar, Vivek; Moritz, Amy E; Keck, Thomas M; Bonifazi, Alessandro; Ellenberger, Michael P; Sibley, Christopher D; Free, Benjamin R; Shi, Lei; Lane, Robert J; Sibley, David R; Newman, Amy Hauck
J Med Chem, 60 (4), pp. 1478–1494, 2017, ISSN: 1520-4804 (Electronic); 0022-2623 (Linking).
[Read More]

Lateral Habenula Involvement in Impulsive Cocaine Seeking

Study Authors Agustin Zapata and Eun-Kyung Hwang

Featured Paper of the Month – June 2017
Zapata, Agustin; Hwang, Eun-Kyung; Lupica, Carl R
Neuropsychopharmacology, 42 (5), pp. 1103–1112, 2016, ISSN: 1740-634X (Electronic); 0893-133X (Linking).
[Read More]

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