Featured Paper of the Month

Featured Paper of the Month – June 2024

Published in Molecular Psychiatry by Marjorie Levinstein and Michael Michaelides, et al. of the NIDA IRP Biobehavioral Imaging and Molecular Neuropsychopharmacology Section.

In this article we performed an in depth in vivo, in vitro, and in silico analysis of (R,S)-methadone and its enantiomers. (S)-methadone is currently in phase III trials as an antidepressant and is frequently referred to as an N-methyl-D-aspartate receptor (NMDAR) antagonist, like ketamine. Here we show that (S)-methadone, like (R)-methadone and (R,S)-methadone is an agonist at the mu opioid receptor (MOR) and does not bind to NMDARs at physiologically relevant concentrations.

Featured Paper of the Month – May 2024

Xylazine, an increasingly abused drug mixed with fentanyl, leads to devastating respiratory issues during fentanyl-xylazine overdose. Despite naloxone being the primary treatment, it falls short in fully reversing the hypoxic effects of the drug mixture. Our study suggests that supplementing naloxone with atipamezole, a xylazine antagonist, provides a more effective and thorough solution for addressing brain hypoxia caused by fentanyl-xylazine mixture.

Featured Paper of the Month – April 2024

Published in Frontiers in Public Health by Salvatore Giorgi and Brenda Curtis,  et al. of the NIDA IRP Technology and Translational Research Unit.

In this work, we apply a computational linguistic framework to measure dehumanization to 3 million news articles. We show that popular media in the U.S. has dehumanized people who used substances to varying degrees. Substances such as heroin have been strongly dehumanized for decades,  while marijuana use is becoming less dehumanized over time, aligning with increased public support for legalization.

Featured Paper of the Month – March 2024
Published in Biological Psychiatry by Xiang Xiao and Yihong Yang,  et al. of the NIDA IRP Magnetic Resonance Imaging and Spectroscopy Section.

Cognitive function and general psychopathology are two important classes of human behavior dimensions that are individually related to mental disorders across diagnostic categories. However, whether these two transdiagnostic dimensions are linked to common or distinct brain networks that convey resilience or risk for the development of psychiatric disorders remains unclear.

Featured Paper of the Month – February 2024
Published in Psychopharmacology by Grant Glatfelter and Michael Baumann et al. of the NIDA IRP Designer Drug Research Unit.

Our findings reveal that nitazenes are potent mu-opioid receptor agonists that induce opioid-like effects in mice. Importantly, we show that certain analogs (e.g., isotonitazene, etonitazene) are much more potent than fentanyl, portending serious risk of overdose and other adverse effects in humans who are exposed to the drugs.

Featured Paper of the Month – January 2024
Published in Current Biology by Brenton Laing and Yeka Aponte, et al. of the NIDA IRP Neuronal Circuits and Behavior Section.

Using techniques including in vivo functional imaging, behavioral paradigms, and neuronal tracing, Laing et al. investigated a small population of parvalbumin neurons in the anterior hypothalamic area (AHA^PV).

Featured Paper of the Month – December 2023
Published in Journal of Medicinal Chemistry by Alessandro Bonifazi , Lily Saab and Amy Hauck Newman of the NIDA IRP Medicinal Chemistry Section.

The Newman Lab published a new generation of dual-target mu opioid receptor (MOR) agonists/dopamine D3 receptor (D3R) antagonists/partial agonists as potentially safer analgesics.

Featured Paper of the Month – November 2023
Published in Translational Psychiatry by Jacqueline Keighron and Gianluigi Tanda, et al. of the NIDA IRP Medication Development Program.

In this study, we show that pretreatments with an inhibitor of CaMKIIα, a kinase that interacts with DAT and regulates synapsin phosphorylation and mobilization of reserve pools of DA vesicles, blunted the effects of cocaine on evoked DA release without affecting cocaine inhibition of DA reuptake.

Featured Paper of the Month – October 2023
Published in Drug and Alcohol Dependence with contributions from Michael Baumann and colleagues from the NIDA IRP.

For this study, we examined the pharmacological effects of non-fentanyl synthetic opioids, including U-47700, brorphine, and isotonitazene, as compared to morphine and fentanyl.

Featured Paper of the Month – September 2023
Published in Neuropsychopharmacology by Yocasta Alvarez-Bagnarol, and Marisela Morales, et al. of the NIDA IRP Neuronal Networks Section.

We demonstrated that inhibition of Dorsal Raphe GABA neurons blocks hyperalgesia (increased pain sensitivity) induced by spontaneous heroin withdrawal.