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Featured Paper of the Month

ESG-1-60 and ESG-1-61: Novel dopamine D receptor-preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents

Omar Soler-Cedeño

Featured Paper of the Month – March 2025

Published in Human Brain Mapping by Justine Hill and Amy Janes, et al. of the NIDA IRP Cognitive and Pharmacological Neuroimaging Unit.

In this study, we show that methylphenidate – a drug used to treat ADHD by increasing dopamine and norepinephrine – boosts the amount of time that the brain is engaged in both internal and external attention networks.

Distributed midbrain responses signal the content of positive identity prediction errors.

Featured Paper of the Month – March 2025

Published in Human Brain Mapping by Justine Hill and Amy Janes, et al. of the NIDA IRP Cognitive and Pharmacological Neuroimaging Unit.

In this study, we show that methylphenidate – a drug used to treat ADHD by increasing dopamine and norepinephrine – boosts the amount of time that the brain is engaged in both internal and external attention networks.

Catecholaminergic Modulation of Large-Scale Network Dynamics Is Tied to the Reconfiguration of Corticostriatal Connectivity

Study Author Justine Hill

Featured Paper of the Month – March 2025

Published in Human Brain Mapping by Justine Hill and Amy Janes, et al. of the NIDA IRP Cognitive and Pharmacological Neuroimaging Unit.

In this study, we show that methylphenidate – a drug used to treat ADHD by increasing dopamine and norepinephrine – boosts the amount of time that the brain is engaged in both internal and external attention networks.

GHSR blockade, but not reduction of peripherally circulating ghrelin via β1-adrenergic receptor antagonism, decreases binge-like alcohol drinking in mice

Rani Richardson

Featured Paper of the Month – February 2025

Published in Molecular Psychiatry by Rani Richardson, Leandro Vendruscolo, and Lorenzo Leggio of the NIDA IRP.

We previously found that systemic and central administration of GHSR antagonists reduced binge-like alcohol drinking, whereas a ghrelin vaccine did not. Thus, we hypothesized that central GHSR drives binge-like alcohol drinking independently of peripheral ghrelin.

Expectancy-related changes in firing of dopamine neurons depend on hippocampus

An illustration of a mouse

Featured Paper of the Month – January 2025

Published in Nature Communications by Zhewei Zhang,  Yuji Takahashi and Geoffrey Schoenbaum et al. of the NIDA IRP Behavioral Neurophysiology Neuroscience Section.

We studied rats with hippocampus damage as they played a smell-based game. The game involved four contexts with different reward structures changing over time.

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet

A portion of The Graphical Abstract for this study. Image copyright: Nature Communications Biology

Featured Paper of the Month – December 2024

Published in Nature Communications Biology by  András H Lékó, Adriana Gregory-Flores and Lorenzo Leggio et al. of the NIDA IRP Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section.

In this study. we investigated whether the deletion of the GHSR gene (GHSR-KO) in rats can prevent or attenuate weight gain caused by a high-fat diet.

VTA glutamatergic projections to the nucleus accumbens suppress psychostimulant-seeking behavior.

A portion of a figure from this study

Featured Paper of the Month – November 2024

Published in Neuropsychopharmacology by  Flavia Barbano and Marisela Morales, et al. of the NIDA IRP Neuronal Networks Section.

Our study shows that activating a parallel VTA-originating glutamatergic pathway targeting the NAc shell can suppress psychostimulant-seeking behavior.

Involvement of dopamine D3 receptor in impulsive choice decision-making in male rats.

Study authors Hui Shen and Zilu Ma

Featured Paper of the Month – October 2024

Published in Neuropharmacology by Hui Shen, Zilu Ma and Yihong Yang, et al. of the NIDA IRP Magnetic Resonance Imaging and Spectroscopy Section.

In this study, we used the delay-discounting task (DDT) to identify rats with different levels of impulsivity.

Lateral hypothalamic glutamatergic inputs to VTA glutamatergic neurons mediate prioritization of innate defensive behavior over feeding

Study authors Flavia Barbano and Marisela Morales

Featured Paper of the Month – August 2024

Published in Nature Communications by Flavia Barbano and Marisela Morales, et al. of the NIDA IRP Neuronal Networks Section.

Defensive behaviors are critical actions evolutionary selected to improve survival. Barbano et al., discovered an unanticipated neuronal pathway that is activated during threatening environmental conditions.

Ecological Momentary Assessment of Self-Reported Kratom Use, Effects, and Motivations Among US Adults

Study authors Kirsten Smith and David Epstein

Featured Paper of the Month – July 2024

Published in Jama Network Open by Kirsten Smith and David Epstein, et al. of the NIDA IRP Real-world Assessment, Prediction, and Treatment Unit.

This was the first-ever study to use real-time, app-based monitoring of patterns and consequences of kratom use, in 357 people who used kratom daily or almost daily.

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