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NIDA IRP

National Institute on Drug Abuse - Intramural Research Program

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  • Electrophysiology Research Home
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Electrophysiology Research Section

Carl R. Lupica, Ph.D.

Carl R. Lupica, Ph.D.

A division of the Cellular and Neurocomputational Systems Branch

Section Chief

Carl R. Lupica, Ph.D.

Contact

Location:
Triad Technology Center
333 Cassell Drive
Room 3302
Baltimore, MD 21224

Phone: 443-740-2123

Fax: 443-740-2123

Email: clupica@mail.nih.gov

About the Lab

The Electrophysiology Research Section conducts investigations in the following areas of study:

Mechanisms of action of abused drugs on synaptic neuronal circuitry:

  • Cannabinoid effects in hippocampus, ventral tegmental area and nucleus accumbens
  • Effects of cannabinoids and cocaine on synaptic plasticity in brain reward circuits

Physiological characterization of Parkinson’s disease in transgenic models:

  • Respiratory chain dysfunction in dopamine neuron mitochondria
  • Dopamine neuron degeneration and early physiological events

Laboratory approaches:

  • Brain slices
  • Patch clamp electrophysiology
  • Confocal microscopy
  • Ultraviolet laser photolysis of caged molecules
  • Electrochemistry of dopamine in brain slices
  • Transgenic models

Electrophysiology Research Section Staff

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Electrophysiology Research Section

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  • Organization
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  • Behavioral Neuroscience Research Branch
  • Integrative Neuroscience Research Branch
  • Translational Addiction Medicine Branch
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