Astrocytes modulate cerebral blood flow and neuronal response to cocaine in prefrontal cortex Mol Psychiatry.
This study introduces a novel multi-channel fluorescence and ultra high-resolution optical coherence Doppler microscope (fl-ODM) that enables simultaneous in vivo imaging of neuronal, astrocytic, and vascular dynamics in the mouse brain. Using this tool, the research uncovers how astrocytes dynamically regulate cocaine-induced changes in cerebral blood flow and neuronal activation in the prefrontal cortex.