Technology Development Initiative Paper of the Month

A chromatin integration labelling method enables epigenomic profiling with lower input. Nature Cell Biology.

Here in the article, authors introduce chromatin integration labelling (ChIL), a technique that combines immunostaining, transposase tagging and linear amplification for low-input epigenome/protein-binding profiling even from single cells. Using ChIL followed by sequencing (ChIL–seq), authors reliably detected the distributions of histone modifications and DNA-binding factors in 100–1,000 cells. [Read More]

Closed-loop wearable naloxone injector system. Scientific Reports.

Chan et al. (2021) have developed a wearable device to detect and reverse an opioid overdose by automatically injecting naloxone to a person who has stopped breathing and moving. This proof-of-principal technology has wide-ranging clinical and commercial potential, including helping to reduce the number of fatal opioid overdoses that could have been prevented if naloxone was available. [Read More]