Closed-loop wearable naloxone injector system
Published in Scientific Reports.
Authors: Justin Chan, Vikram Iyer, Anran Wang, Alexander Lyness, Preetma Kooner, Jacob Sunshine & Shyamnath Gollakota
Paper presented by Dr. Albert Burgess-Hull and selected by the NIDA TDI Paper of the Month Committee
Opioid overdose deaths in the US are the highest they have ever been in history. Although the opioid antagonist Naloxone can rapidly reverse an opioid overdose, a bystander/partner still needs to be present to administer the lifesaving drug. Chan et al. (2021) have developed a wearable device to detect and reverse an opioid overdose by automatically injecting naloxone to a person who has stopped breathing and moving. The small device is worn on the stomach, much like an automated insulin pump. This proof-of-principal technology has wide-ranging clinical and commercial potential, including helping to reduce the number of fatal opioid overdoses that could have been prevented if naloxone was available.