Reviews To Read – August 28, 2018. The increasing use of marijuana, its derivatives, and synthetic cannabinoids for medicinal and recreational purposes has increased interest in understanding the addictive potential of this class of molecules. Studies show that nearly 1 in 10 marijuana users will eventually show signs of dependence on the drug, which is… [Read More]
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Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving.
Featured Paper of the Month – August 2018
Published in The Journal of Neuroscience by Li, Xuan; Witonsky, Kailyn R; Lofaro, Olivia M; Surjono, Felicia; Zhang, Jianjun; Bossert, Jennifer M; Shaham, Yavin
Methamphetamine seeking progressively increases after withdrawal from drug self-administration, a phenomenon termed incubation of methamphetamine craving. We previously found that D1R-mediated dopamine transmission in dorsomedial striatum plays a critical role in this incubation phenomenon. Here, we used neuroanatomical and neuropharmacological methods in rats to demonstrate that an interaction between the glutamatergic projection from the lateral anterior intralaminar nuclei of thalamus to dorsomedial striatum and local dopamine D1Rs plays a critical role in relapse to methamphetamine seeking after prolonged withdrawal…
Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task.
Featured Paper of the Month – July 2018
Published in Elife by Sadacca, Brian F; Wied, Heather M; Lopatina, Nina; Saini, Gurpreet K; Nemirovsky, Daniel; Schoenbaum, Geoffrey
Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation of associative structure or cognitive maps. Here we tested between these accounts by recording OFC neurons in rats during an OFC-dependent sensory preconditioning task…
Context-induced relapse after extinction versus punishment: similarities and differences.
Reviews To Read – June 14, 2018. This review, which is part of a special issue of Psychopharmacology on “Extinction” summarizes recent research on similarities and differences in the neuronal mechanisms of context-induced relapse after extinction-imposed abstinence (the classical model) versus context-induced relapse after punishment-imposed abstinence (the new model).
Navigating Your Life Without Losing Yourself
Tuesday June 19, 2018 • 2 – 3 pm in the BRC Atrium Panel discussion on mental health in college & career Topics will include: Self-identity Managing recovery Managing stress and workload Warning signs Seeking support and help Mentoring students Supporting marginalized students Advocating for yourself Bring your questions for the panelists or submit anonymously via… [Read More]
Delta Rhythm Orchestrates the Neural Activity Underlying the Resting State BOLD Signal via Phase–amplitude Coupling.
Featured Paper of the Month – June 2018
Published in Cerebral Cortex by Jaime, Saul; Gu, Hong; Sadacca, Brian F; Stein, Elliot A; Cavazos, Jose E; Yang, Yihong; Lu, Hanbing
Our brains always work, consciously or unconsciously. Functional connectivity MRI has identified so-called resting state brain networks (e.g. default mode network). Aberrant activity in such networks is implicated in neurological and psychiatric disorders. This work applies simultaneous electrophysiological recording and functional MRI to investigate the neurophysiological basis of the network activity…
The Coffeehouse: Art of Recovery
The NIDA Eliminating Stigma Team held its first coffeehouse event on Thursday May 10th, titled “The Coffeehouse: Art of Recovery.” The audience experienced powerful stories of struggle and triumph over mental illness and drug addiction through performances and presentations of poetry, spoken word, visual art, photography, and music. The event turned the atrium into a… [Read More]
The Coffeehouse: Art of Recovery
Join the NIDA IRP for an Eliminating Stigma Series event. Experience stories of struggle and triumph over addiction and mental illness through spoken word, art, and music. Coffee and light refreshments will be served. May 10, 1:00 pm – 2:30 pm in the Biomedical Research Center Atrium.
Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature.
Featured Paper of the Month – May 2018
Published in Neuropsychopharmacology by Solis, Ernesto Jr; Cameron-Burr, Keaton T; Shaham, Yavin; Kiyatkin, Eugene A
Fentanyl is a potent synthetic opioid used clinically to treat pain and as a general anesthetic. Recently, fentanyl has emerged as a recreational drug and its overdose has been linked to numerous deaths in the US. To better understand how fentanyl affects the brain, we used electrochemical techniques in rats and examined the effect of intravenous fentanyl on oxygen and glucose levels in the nucleus accumbens, a brain region implicated in reward and addiction…
Yihong Yang inducted as a Fellow of the American Institute for Medical and Biological Engineering
The American Institute for Medical and Biological Engineering (AIMBE) has announced the induction of Yihong Yang, Ph.D., Senior Investigator and Chief of the Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Drug Abuse, National Institutes of Health to its College of Fellows. Dr. Yang was nominated, reviewed, and elected by peers and members of… [Read More]
