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Featured Paper of the Month

Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders

July 2016 Featured Paper Image - Small

Featured Paper of the Month – July 2016
Published in Natural Neuroscience by Zhang, Wen; Zhang, Lifeng; Liang, Bo; Schroeder, David; Zhang, Zhong-Wei; Cox, Gregory A; Li, Yun; Lin, Da-Ting

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown. Using TDP-43(A315T) mice, an ALS and FTD model with marked cortical pathology, we found that hyperactive somatostatin interneurons disinhibited layer 5 pyramidal neurons (L5-PNs) and contributed to their excitotoxicity…

Local Control of Extracellular Dopamine Levels in the Medial Nucleus Accumbens by a Glutamatergic Projection from the Infralimbic Cortex

June 2016 Featured Paper Image - Small

Featured Paper of the Month – June 2016
Published in The Journal of Neuroscience by Quiroz, Cesar; Orru, Marco; Rea, William; Ciudad-Roberts, Andres; Yepes, Gabriel; Britt, Jonathan P; Ferre, Sergi

It is generally assumed that infralimbic cortex (ILC) and prelimbic cortex, two adjacent areas of the medial prefrontal cortex (mPFC) in rodents, provide selective excitatory glutamatergic inputs to the nucleus accumbens (NAc) shell and core, respectively…

Neural estimates of imagined outcomes in the orbitofrontal cortex drive behavior and learning

May 2016 Featured Papers Image - Small

Featured Paper of the Month – May 2016
Published in Neuron by Takahashi, Yuji K; Chang, Chun Yun; Lucantonio, Federica; Haney, Richard Z; Berg, Benjamin A; Yau, Hau-Jie; Bonci, Antonello; Schoenbaum, Geoffrey

Imagination, defined as the ability to interpret reality in ways that diverge from past experience, is fundamental to adaptive behavior. This can be seen at a simple level in our capacity to predict novel outcomes in new situations. The ability to anticipate outcomes never before received can also influence learning if those imagined outcomes are not received…

The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys

April 2016 Featured Papers Image - Small

Featured Paper of the Month – April 2016
Published in Biological Psychiatry by Justinova, Zuzana; Panlilio, Leigh V; Secci, Maria E; Redhi, Godfrey H; Schindler, Charles W; Cross, Alan J; Mrzljak, Ladislav; Medd, Amy; Shaham, Yavin; Goldberg, Steven R

Based on rodent studies, group II metabotropic glutamate receptors (mGluR2 and mGluR3) were suggested as targets for addiction treatment. However, LY379268 and other group II agonists do not discriminate between the mainly presynaptic inhibitory mGluR2 (the proposed treatment target) and mGluR3. These agonists also produce tolerance over repeated administration and are no longer considered for addiction treatment…

Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model

March 2016 Featured Papers Image - Small

Featured Paper of the Month – March 2016
Published in Biological Psychiatry by Caprioli, Daniele; Venniro, Marco; Zeric, Tamara; Li, Xuan; Adhikary, Sweta; Madangopal, Rajtarun; Marchant, Nathan J; Lucantonio, Federica; Schoenbaum, Geoffrey; Bossert, Jennifer M; Shaham, Yavin

Cue-induced methamphetamine craving increases after prolonged forced (experimenter-imposed) abstinence from the drug (incubation of methamphetamine craving). Here, we determined whether this incubation phenomenon would occur under conditions that promote voluntary (self-imposed) abstinence…

Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area

February 2016 Featured Paper Image - Small

Featured Paper of the Month – February 2016
Published in Cell Reports by Wang, Huikun; Treadway, Tyler; Covey, Daniel P; Cheer, Joseph F; Lupica, Carl R

Cocaine is a highly addictive drug that acts upon the brain’s reward circuitry via the inhibition of monoamine uptake. Endogenous cannabinoids (eCB) are lipid molecules released from midbrain dopamine (DA) neurons that modulate cocaine’s effects through poorly understood mechanisms…

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

January 2016 Featured Paper Image - Small

Featured Paper of the Month – January 2016
Published in The Journal of Medical Chemistry by Boateng, Comfort A; Bakare, Oluyomi M; Zhan, Jia; Banala, Ashwini K; Burzynski, Caitlin; Pommier, Elie; Keck, Thomas M; Donthamsetti, Prashant; Javitch, Jonathan A; Rais, Rana; Slusher, Barbara S; Xi, Zheng-Xiong; Newman, Amy Hauck

The dopamine D3 receptor (D3R) is a promising target for the development of pharmacotherapeutics to treat substance use disorders. Several D3R-selective antagonists are effective in animal models of drug abuse, especially in models of relapse. Nevertheless, poor bioavailability, metabolic instability, and/or predicted toxicity have impeded success in translating these drug candidates to clinical use…

Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.

December 2015 Featured Papers Image - Small

Featured Paper of the Month – December 2015
Published in The Journal of Medical Chemistry by Selfridge, Brandon R; Wang, Xiaohui; Zhang, Yingning; Yin, Hang; Grace, Peter M; Watkins, Linda R; Jacobson, Arthur E; Rice, Kenner C

Activation of Toll-like receptors has been linked to neuropathic pain and opioid dependence. (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been shown to reverse neuropathic pain in rat studies. We designed and synthesized compounds based on (+)-naltrexone and (+)-noroxymorphone and evaluated their TLR4 antagonist activities by their effects on inhibiting lipopolysaccharide (LPS) induced TLR4 downstream nitric oxide (NO) production in microglia BV-2 cells…

Impaired functional connectivity within and between frontostriatal circuits and its association with compulsive drug use and trait impulsivity in cocaine addiction.

November 2015 Featured Papers Image - Small

Featured Paper of the Month – November 2015
Published in JAMA Psychiatry by Hu, Yuzheng; Salmeron, Betty Jo; Gu, Hong; Stein, Elliot A; Yang, Yihong

Converging evidence has long identified both impulsivity and compulsivity as key psychological constructs in drug addiction. Although dysregulated striatal-cortical network interactions have been identified in cocaine addiction, the association between these brain networks and addiction is poorly understood…

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

October 2015 Featured Papers Image

Featured Paper of the Month – October 2015
Published in The Journal of Biological Chemistry by Stolzenberg, Sebastian; Quick, Matthias; Zhao, Chunfeng; Gotfryd, Kamil; Khelashvili, George; Gether, Ulrik; Loland, Claus J; Javitch, Jonathan A; Noskov, Sergei; Weinstein, Harel; Shi, Lei

Neurotransmitter:sodium symporters (NSSs) terminate neurotransmission by Na(+)-dependent reuptake of released neurotransmitters. Previous studies suggested that Na(+)-binding reconfigures dynamically coupled structural elements in an allosteric interaction network (AIN) responsible for function-related conformational changes, but the intramolecular pathway of this mechanism has remained uncharted…

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  • Home
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    • Featured Paper of the Month
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    • About NIDA IRP
    • Contact Us
    • Directions and Map
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    • Faculty
    • Office of the Scientific Director
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    • Administrative Management Branch
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    • Cellular and Neurocomputational Systems Branch
    • Molecular Neuropsychiatry Research Branch
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