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Khorshada Jahan, Ph.D.

Khorshada Jahan, Ph.D.

Position

Post-doctoral IRTA Fellow, Medicinal Chemistry Section

Contact

Triad Technology Center
333 Cassell Drive
Baltimore, MD 21224

Email: khorshada.jahan@nih.gov

Education

Ph.D. – Organic Chemistry, University of Wisconsin-Milwaukee

M.S. – Organic Chemistry, University of Dhaka, Bangladesh

B.S. – Chemistry, University of Dhaka, Bangladesh

Research Interests

Khorshada Jahan completed her dissertation under the guidance of Prof. M Mahmun Hossain at the University of Wisconsin-Milwaukee. While a graduate student there, she developed a method to synthesize natural products Tryprosatin A and B (a potential anti-cancer agent) and its analogs in only four steps. Looking to cultivate her interest in design and synthesize new compounds and methods, Khorshada joined the Medicinal Chemistry Section in NIDA in 2022, guided by Dr. Amy H. Newman. Since then, she has been working on various research projects related to the design and synthesis of ligands that can effectively bind to both dopamine D3 and mu opioid receptors that may provide new leads for opioid analgesics with lower addictive liability. She is also working on novel fluorescent ligands directed toward mu opioid receptors.

Selected Publications

2021

Rahaman, Mizzanoor; Ali, M Shahnawaz; Jahan, Khorshada; Hinz, Damon; Belayet, Jawad Bin; Majinski, Ryan; Hossain, M Mahmun

Synthetic Scope of Brønsted Acid-Catalyzed Reactions of Carbonyl Compounds and Ethyl Diazoacetate Journal Article

In: J Org Chem, vol. 86, no. 9, pp. 6138–6147, 2021, ISSN: 1520-6904.

Abstract | Links

@article{pmid33844917,
title = {Synthetic Scope of Brønsted Acid-Catalyzed Reactions of Carbonyl Compounds and Ethyl Diazoacetate},
author = {Mizzanoor Rahaman and M Shahnawaz Ali and Khorshada Jahan and Damon Hinz and Jawad Bin Belayet and Ryan Majinski and M Mahmun Hossain},
url = {https://pubmed.ncbi.nlm.nih.gov/33844917/},
doi = {10.1021/acs.joc.0c02972},
issn = {1520-6904},
year = {2021},
date = {2021-05-01},
urldate = {2021-05-01},
journal = {J Org Chem},
volume = {86},
number = {9},
pages = {6138--6147},
abstract = {The comprehensive study of the reactions of carbonyl compounds and ethyl diazoacetate in the presence of a Brønsted acid catalyst is described. In result, a broad range of 3-oxo-esters were synthesized from a variety of ketones and aliphatic aldehydes by 1,2-aryl/alkyl/hydride shift. Aryl-methyl ketones produced only aryl-migrated products, whereas other ketones yielded a mixture of products. For diaryl ketones, the identity of two inseparable migrated products was confirmed by two-dimensional NMR spectroscopy.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Close

The comprehensive study of the reactions of carbonyl compounds and ethyl diazoacetate in the presence of a Brønsted acid catalyst is described. In result, a broad range of 3-oxo-esters were synthesized from a variety of ketones and aliphatic aldehydes by 1,2-aryl/alkyl/hydride shift. Aryl-methyl ketones produced only aryl-migrated products, whereas other ketones yielded a mixture of products. For diaryl ketones, the identity of two inseparable migrated products was confirmed by two-dimensional NMR spectroscopy.

Close

  • https://pubmed.ncbi.nlm.nih.gov/33844917/
  • doi:10.1021/acs.joc.0c02972

Close

Jahan, Khorshada; Khan, Kaif Rashid; Akhter, Kawsari; Romman, Umme Kulsum Rowzatur; Halim, Ershad

A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study Journal Article

In: PLoS One, vol. 16, no. 3, pp. e0247619, 2021, ISSN: 1932-6203.

Abstract | Links

@article{pmid33661961,
title = {A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study},
author = {Khorshada Jahan and Kaif Rashid Khan and Kawsari Akhter and Umme Kulsum Rowzatur Romman and Ershad Halim},
url = {https://pubmed.ncbi.nlm.nih.gov/33661961/},
doi = {10.1371/journal.pone.0247619},
issn = {1932-6203},
year = {2021},
date = {2021-01-01},
urldate = {2021-01-01},
journal = {PLoS One},
volume = {16},
number = {3},
pages = {e0247619},
abstract = {Thiazolidinediones are very important and used as a drug for the treatment of type 2 diabetes. Here, we report a convenient approach to synthesis 3-m-tolyl-5-arylidene-2,4-thiazolidinediones (TZDs) derivatives 7a-e in two steps with moderate to good yield using morpholine as a catalyst. All the structures were confirmed by their spectral IR, 1H NMR and 13C NMR data. The anti-diabatic activity of all synthesized molecules is evaluated by docking with peroxisome proliferator-activated receptor-γ (PPARγ). Preliminary flexible docking studies reveals that our compounds 7a, 7d and 7e showed better binding affinity with the protein and could be a potential candidate for the treatment of type 2 diabetes in near future.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Close

Thiazolidinediones are very important and used as a drug for the treatment of type 2 diabetes. Here, we report a convenient approach to synthesis 3-m-tolyl-5-arylidene-2,4-thiazolidinediones (TZDs) derivatives 7a-e in two steps with moderate to good yield using morpholine as a catalyst. All the structures were confirmed by their spectral IR, 1H NMR and 13C NMR data. The anti-diabatic activity of all synthesized molecules is evaluated by docking with peroxisome proliferator-activated receptor-γ (PPARγ). Preliminary flexible docking studies reveals that our compounds 7a, 7d and 7e showed better binding affinity with the protein and could be a potential candidate for the treatment of type 2 diabetes in near future.

Close

  • https://pubmed.ncbi.nlm.nih.gov/33661961/
  • doi:10.1371/journal.pone.0247619

Close

Rahaman, Mizzanoor; Ali, M. Shahnawaz; Jahan, Khorshada; Belayet, Jawad Bin; Rahman, A. F. M. Towheedur; Hossain, M. Mahmun

Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications Journal Article

In: Org. Chem. Front., vol. 8, iss. 1, pp. 169-191, 2021.

Abstract | Links

@article{D0QO01157F,
title = {Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications},
author = {Mizzanoor Rahaman and M. Shahnawaz Ali and Khorshada Jahan and Jawad Bin Belayet and A. F. M. Towheedur Rahman and M. Mahmun Hossain},
url = {http://dx.doi.org/10.1039/D0QO01157F},
doi = {10.1039/D0QO01157F},
year = {2021},
date = {2021-01-01},
urldate = {2021-01-01},
journal = {Org. Chem. Front.},
volume = {8},
issue = {1},
pages = {169-191},
publisher = {The Royal Society of Chemistry},
abstract = {The discovery of the 3-hydroxy-2-aryl acrylate was a significant breakthrough in the field of organic and medicinal chemistry. Due to the presence of both electrophilic and nucleophilic centers, this scaffold acts as a fascinating building block of many bioactive compounds. More importantly, 3-hydroxy-2-aryl acrylate is a vital precursor in the synthesis of natural products and in the development of essential drugs. In this first review, we outline different approaches for preparing 3-hydroxy-2-aryl acrylate with mechanisms and its application in a variety of chemical fields.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Close

The discovery of the 3-hydroxy-2-aryl acrylate was a significant breakthrough in the field of organic and medicinal chemistry. Due to the presence of both electrophilic and nucleophilic centers, this scaffold acts as a fascinating building block of many bioactive compounds. More importantly, 3-hydroxy-2-aryl acrylate is a vital precursor in the synthesis of natural products and in the development of essential drugs. In this first review, we outline different approaches for preparing 3-hydroxy-2-aryl acrylate with mechanisms and its application in a variety of chemical fields.

Close

  • http://dx.doi.org/10.1039/D0QO01157F
  • doi:10.1039/D0QO01157F

Close

2019

Akhter, K; Jahan, K; Halim, ME; Shefa, S; Rifat, S; Khan, KR; Ahmed, SM; Romman, UKR

Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity Journal Article

In: Bangladesh Journal of Scientific and Industrial Research, vol. 54, no. 1, pp. 47–54, 2019.

Links

@article{Akhter_Jahan_Halim_Shefa_Rifat_Khan_Ahmed_Romman_2019,
title = {Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity},
author = {K Akhter and K Jahan and ME Halim and S Shefa and S Rifat and KR Khan and SM Ahmed and UKR Romman},
url = {https://www.banglajol.info/index.php/BJSIR/article/view/40730},
doi = {10.3329/bjsir.v54i1.40730},
year = {2019},
date = {2019-03-01},
urldate = {2019-03-01},
journal = {Bangladesh Journal of Scientific and Industrial Research},
volume = {54},
number = {1},
pages = {47--54},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Close

  • https://www.banglajol.info/index.php/BJSIR/article/view/40730
  • doi:10.3329/bjsir.v54i1.40730

Close

2018

Mahmud, Al; Halim, ME; Ali, MK; Kabir, MA; Akhter, K; Jahan, K; Romman, UKR

One pot synthesis of 2- amino-5-oxo-4-aryl-5, 6, 7, 8-tetrahydro- 4Hchromenes- 3-carboxilic acid ethyl esters Journal Article

In: Bangladesh Journal of Scientific and Industrial Research, vol. 53, no. 1, pp. 35–40, 2018.

Links

@article{Mahmud_Halim_Ali_Kabir_Akhter_Jahan_Romman_2018,
title = {One pot synthesis of 2- amino-5-oxo-4-aryl-5, 6, 7, 8-tetrahydro- 4Hchromenes- 3-carboxilic acid ethyl esters},
author = {Al Mahmud and ME Halim and MK Ali and MA Kabir and K Akhter and K Jahan and UKR Romman},
url = {https://www.banglajol.info/index.php/BJSIR/article/view/35908},
doi = {10.3329/bjsir.v53i1.35908},
year = {2018},
date = {2018-03-01},
urldate = {2018-03-01},
journal = {Bangladesh Journal of Scientific and Industrial Research},
volume = {53},
number = {1},
pages = {35--40},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Close

  • https://www.banglajol.info/index.php/BJSIR/article/view/35908
  • doi:10.3329/bjsir.v53i1.35908

Close

2017

Akhter, K; Halim, ME; Ahmed, SM; Sarkar, PK; Akter, F; Jahan, K; Romman, UKR; Ahmed, MG

One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II Journal Article

In: Bangladesh Journal of Scientific and Industrial Research, vol. 52, no. 2, pp. 115–124, 2017.

Links

@article{Akhter_Halim_Ahmed_Sarkar_Akter_Jahan_Romman_Ahmed_2017,
title = {One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II},
author = {K Akhter and ME Halim and SM Ahmed and PK Sarkar and F Akter and K Jahan and UKR Romman and MG Ahmed},
url = {https://www.banglajol.info/index.php/BJSIR/article/view/32921},
doi = {10.3329/bjsir.v52i2.32921},
year = {2017},
date = {2017-06-01},
urldate = {2017-06-01},
journal = {Bangladesh Journal of Scientific and Industrial Research},
volume = {52},
number = {2},
pages = {115--124},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Close

  • https://www.banglajol.info/index.php/BJSIR/article/view/32921
  • doi:10.3329/bjsir.v52i2.32921

Close

2016

Akhter, K; Ahmed, SM; Halim, Md E; Kader, MA; Jahan, K; Romman, UKR; Ahmed, MG

One step cyclocondensation of (thio)barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide: Part-I Journal Article

In: Bangladesh Journal of Scientific and Industrial Research, vol. 51, no. 2, pp. 129–138, 2016.

Links

@article{Akhter_Ahmed_Halim_Kader_Jahan_Romman_Ahmed_2016,
title = {One step cyclocondensation of (thio)barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide: Part-I},
author = {K Akhter and SM Ahmed and Md E Halim and MA Kader and K Jahan and UKR Romman and MG Ahmed},
url = {https://www.banglajol.info/index.php/BJSIR/article/view/28110},
doi = {10.3329/bjsir.v51i2.28110},
year = {2016},
date = {2016-06-01},
urldate = {2016-06-01},
journal = {Bangladesh Journal of Scientific and Industrial Research},
volume = {51},
number = {2},
pages = {129--138},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Close

  • https://www.banglajol.info/index.php/BJSIR/article/view/28110
  • doi:10.3329/bjsir.v51i2.28110

Close

Rifat, Samia; Jahan, Khorshada; Romman, U. K. R.; Akhter, Kawsari; Halim, Md. Ershad

A Green Approach to Synthesize and in vitro Antimicrobial Activity of Indeno-Imidazole Derivatives and Ninhydrin-Nucleophile Adducts Journal Article

In: Asian Journal of Chemistry, vol. 28, no. 7, pp. 1611-1616, 2016.

Abstract | Links

@article{Rifat2016,
title = {A Green Approach to Synthesize and in vitro Antimicrobial Activity of Indeno-Imidazole Derivatives and Ninhydrin-Nucleophile Adducts},
author = {Samia Rifat and Khorshada Jahan and U.K.R. Romman and Kawsari Akhter and Md. Ershad Halim},
doi = {https://doi.org/10.14233/ajchem.2016.19775},
year = {2016},
date = {2016-01-01},
journal = {Asian Journal of Chemistry},
volume = {28},
number = {7},
pages = {1611-1616},
abstract = {Ninhydrin (1) reacted with weak nitrogen nucleophiles (2a-2f) in the presence of H2O/EtOH medium to give the corresponding indeno-imidazole derivatives (3a-3d) and ninhydrin-nucleophile adducts (3e-3f). The structures of the compounds (3a-3f) were confirmed by their UV, IR, 1H NMR, 13C NMR spectra and elemental analyses. The synthesized compounds were evaluated for their antimicrobial activity by Kirby-Bauer disk diffusion method. Most of the compounds showed good to moderate antimicrobial activity.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Close

Ninhydrin (1) reacted with weak nitrogen nucleophiles (2a-2f) in the presence of H2O/EtOH medium to give the corresponding indeno-imidazole derivatives (3a-3d) and ninhydrin-nucleophile adducts (3e-3f). The structures of the compounds (3a-3f) were confirmed by their UV, IR, 1H NMR, 13C NMR spectra and elemental analyses. The synthesized compounds were evaluated for their antimicrobial activity by Kirby-Bauer disk diffusion method. Most of the compounds showed good to moderate antimicrobial activity.

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  • doi:https://doi.org/10.14233/ajchem.2016.19775

Close

2015

Akhter, Kawsari; Jahan, Khorshada; Romman, U. K. R.; Ahmed, Md; Rahman, Md; Al-Amin, Md

A Green Approach to Synthesize Dihydropyrimidinone Derivatives by Using Anhydrous ZnCl2 Catalyst Under Refluxing Condition in Heptane-Toluene Medium via Biginelli Reaction Journal Article

In: Asian Journal of Chemistry, vol. 27, pp. 2624-2626, 2015.

Links

@article{articlec,
title = {A Green Approach to Synthesize Dihydropyrimidinone Derivatives by Using Anhydrous ZnCl2 Catalyst Under Refluxing Condition in Heptane-Toluene Medium via Biginelli Reaction},
author = {Kawsari Akhter and Khorshada Jahan and U. K. R. Romman and Md Ahmed and Md Rahman and Md Al-Amin},
doi = {10.14233/ajchem.2015.18615},
year = {2015},
date = {2015-01-01},
urldate = {2015-01-01},
journal = {Asian Journal of Chemistry},
volume = {27},
pages = {2624-2626},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

Close

  • doi:10.14233/ajchem.2015.18615

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2013

Jaman, Zinia; Jahan, Khorshada; Akhter, Kawsari; Ahmed, S. Mosaddeq; Siddiki, S M A; Ahmed, Md

An efficient synthesis of chromene derivatives through a tandem michael addition-cyclization reaction. Journal Article

In: J. Bangladesh Chem. Soc., vol. 26, pp. 75–82, 2013.

@article{Jaman:2013aa,
title = {An efficient synthesis of chromene derivatives through a tandem michael addition-cyclization reaction.},
author = {Zinia Jaman and Khorshada Jahan and Kawsari Akhter and S. Mosaddeq Ahmed and S M A Siddiki and Md Ahmed},
year = {2013},
date = {2013-01-01},
urldate = {2013-01-01},
journal = {J. Bangladesh Chem. Soc.},
volume = {26},
pages = {75--82},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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2011

Ahmed, M. Giasuddin; Romman, U. K. R.; Akhter, Kawsari; Jahan, Khorshada; Bhuiyan, M. Nazmul Hasan; Halim, M. Ershad

Synthesis of Substituted Tetrahydrochromenes by the Reactions of α,β-Unsaturated Cyanoesters with Dimedone/1,3-Cyclohexanedione Journal Article

In: Synthetic Communications, vol. 41, no. 19, pp. 2822-2827, 2011.

Abstract | Links

@article{doi:10.1080/00397911.2010.515346,
title = {Synthesis of Substituted Tetrahydrochromenes by the Reactions of α,β-Unsaturated Cyanoesters with Dimedone/1,3-Cyclohexanedione},
author = {M. Giasuddin Ahmed and U. K. R. Romman and Kawsari Akhter and Khorshada Jahan and M. Nazmul Hasan Bhuiyan and M. Ershad Halim},
url = {https://doi.org/10.1080/00397911.2010.515346},
doi = {10.1080/00397911.2010.515346},
year = {2011},
date = {2011-01-01},
urldate = {2011-01-01},
journal = {Synthetic Communications},
volume = {41},
number = {19},
pages = {2822-2827},
publisher = {Taylor & Francis},
abstract = { Abstract Ethyl esters of 2-cyano-3-arylacrylic acid 1a--d (a = 4-CH3-C6H4-},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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Abstract Ethyl esters of 2-cyano-3-arylacrylic acid 1a--d (a = 4-CH3-C6H4-

Close

  • https://doi.org/10.1080/00397911.2010.515346
  • doi:10.1080/00397911.2010.515346

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