Contact
Triad Technology Center333 Cassell Drive
Baltimore, MD 21224
Email: khorshada.jahan@nih.gov
Education
Ph.D. – Organic Chemistry, University of Wisconsin-Milwaukee
M.S. – Organic Chemistry, University of Dhaka, Bangladesh
B.S. – Chemistry, University of Dhaka, Bangladesh
Research Interests
Khorshada Jahan completed her dissertation under the guidance of Prof. M Mahmun Hossain at the University of Wisconsin-Milwaukee. While a graduate student there, she developed a method to synthesize natural products Tryprosatin A and B (a potential anti-cancer agent) and its analogs in only four steps. Looking to cultivate her interest in design and synthesize new compounds and methods, Khorshada joined the Medicinal Chemistry Section in NIDA in 2022, guided by Dr. Amy H. Newman. Since then, she has been working on various research projects related to the design and synthesis of ligands that can effectively bind to both dopamine D3 and mu opioid receptors that may provide new leads for opioid analgesics with lower addictive liability. She is also working on novel fluorescent ligands directed toward mu opioid receptors.
Selected Publications
Synthetic Scope of Brønsted Acid-Catalyzed Reactions of Carbonyl Compounds and Ethyl Diazoacetate Journal Article In: J Org Chem, vol. 86, no. 9, pp. 6138–6147, 2021, ISSN: 1520-6904. In: PLoS One, vol. 16, no. 3, pp. e0247619, 2021, ISSN: 1932-6203. Chemistry of 3-hydroxy-2-aryl acrylate: syntheses, mechanisms, and applications Journal Article In: Org. Chem. Front., vol. 8, iss. 1, pp. 169-191, 2021. Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity Journal Article In: Bangladesh Journal of Scientific and Industrial Research, vol. 54, no. 1, pp. 47–54, 2019. One pot synthesis of 2- amino-5-oxo-4-aryl-5, 6, 7, 8-tetrahydro- 4Hchromenes- 3-carboxilic acid ethyl esters Journal Article In: Bangladesh Journal of Scientific and Industrial Research, vol. 53, no. 1, pp. 35–40, 2018. One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II Journal Article In: Bangladesh Journal of Scientific and Industrial Research, vol. 52, no. 2, pp. 115–124, 2017. One step cyclocondensation of (thio)barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide: Part-I Journal Article In: Bangladesh Journal of Scientific and Industrial Research, vol. 51, no. 2, pp. 129–138, 2016. A Green Approach to Synthesize and in vitro Antimicrobial Activity of Indeno-Imidazole Derivatives and Ninhydrin-Nucleophile Adducts Journal Article In: Asian Journal of Chemistry, vol. 28, no. 7, pp. 1611-1616, 2016. In: Asian Journal of Chemistry, vol. 27, pp. 2624-2626, 2015. An efficient synthesis of chromene derivatives through a tandem michael addition-cyclization reaction. Journal Article In: J. Bangladesh Chem. Soc., vol. 26, pp. 75–82, 2013. Synthesis of Substituted Tetrahydrochromenes by the Reactions of α,β-Unsaturated Cyanoesters with Dimedone/1,3-Cyclohexanedione Journal Article In: Synthetic Communications, vol. 41, no. 19, pp. 2822-2827, 2011.2021
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