Contact
Biomedical Research Center251 Bayview Boulevard
Baltimore, MD 21224
Email: john.fedota@nih.gov
Education
B.A. - Biology, Oberlin College
M.A. and Ph.D. - Psychology, George Mason University
Research Interests
John Fedota received a B.A. in Biology from Oberlin College and an M.A. and Ph.D. in Psychology from George Mason University. Prior to joining the NRB, he was a research fellow at the Center of Excellence in Neuroergonomics and Technology (CENTEC) at George Mason University. His research focuses on the intersection of executive control, reward, and attention.
In the NRB, Dr. Fedota investigates the neural mechanisms of smoking cessation. Specific projects include:
- Development of biomarkers predictive of smoking cessation success
- Investigation of the effects of psilocybin on treatment seeking smokers
- Characterization of the neurobiological mechanisms of varenicline’s clinical efficacy
- Description of the effects of e-cigarette use on smokers
Publications
Selected Publications
2016
Fedota, John R; Matous, Allison L; Salmeron, Betty Jo; Gu, Hong; Ross, Thomas J; Stein, Elliot A
In: Neuropsychopharmacology, vol. 41, no. 10, pp. 2557–2565, 2016, ISSN: 1740-634X (Electronic); 0893-133X (Linking).
@article{Fedota2016,
title = {Insula Demonstrates a Non-Linear Response to Varying Demand for Cognitive Control and Weaker Resting Connectivity With the Executive Control Network in Smokers.},
author = {John R Fedota and Allison L Matous and Betty Jo Salmeron and Hong Gu and Thomas J Ross and Elliot A Stein},
url = {https://www.ncbi.nlm.nih.gov/pubmed/27112116},
doi = {10.1038/npp.2016.62},
issn = {1740-634X (Electronic); 0893-133X (Linking)},
year = {2016},
date = {2016-04-26},
journal = {Neuropsychopharmacology},
volume = {41},
number = {10},
pages = {2557--2565},
address = {Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.},
abstract = {Deficits in cognitive control processes are a primary characteristic of nicotine addiction. However, while network-based connectivity measures of dysfunction have frequently been observed, empirical evidence of task-based dysfunction in these processes has been inconsistent. Here, in a sample of smokers (n=35) and non-smokers (n=21), a previously validated parametric flanker task is employed to characterize addiction-related alterations in responses to varying (ie, high, intermediate, and low) demands for cognitive control. This approach yields a demand-response curve that aims to characterize potential non-linear responses to increased demand for control, including insensitivities or lags in fully activating the cognitive control network. We further used task-based differences in activation between groups as seeds for resting-state analysis of network dysfunction in an effort to more closely link prior inconsistencies in task-related activation with evidence of impaired network connectivity in smokers. For both smokers and non-smokers, neuroimaging results showed similar increases in activation in brain areas associated with cognitive control. However, reduced activation in right insula was seen only in smokers and only when processing intermediate demand for cognitive control. Further, in smokers, this task-modulated right insula showed weaker functional connectivity with the superior frontal gyrus, a component of the task-positive executive control network. These results demonstrate that the neural instantiation of salience attribution in smokers is both more effortful to fully activate and has more difficulty communicating with the exogenous, task-positive, executive control network. Together, these findings further articulate the cognitive control dysfunction associated with smoking and illustrate a specific brain circuit potentially responsible.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Deficits in cognitive control processes are a primary characteristic of nicotine addiction. However, while network-based connectivity measures of dysfunction have frequently been observed, empirical evidence of task-based dysfunction in these processes has been inconsistent. Here, in a sample of smokers (n=35) and non-smokers (n=21), a previously validated parametric flanker task is employed to characterize addiction-related alterations in responses to varying (ie, high, intermediate, and low) demands for cognitive control. This approach yields a demand-response curve that aims to characterize potential non-linear responses to increased demand for control, including insensitivities or lags in fully activating the cognitive control network. We further used task-based differences in activation between groups as seeds for resting-state analysis of network dysfunction in an effort to more closely link prior inconsistencies in task-related activation with evidence of impaired network connectivity in smokers. For both smokers and non-smokers, neuroimaging results showed similar increases in activation in brain areas associated with cognitive control. However, reduced activation in right insula was seen only in smokers and only when processing intermediate demand for cognitive control. Further, in smokers, this task-modulated right insula showed weaker functional connectivity with the superior frontal gyrus, a component of the task-positive executive control network. These results demonstrate that the neural instantiation of salience attribution in smokers is both more effortful to fully activate and has more difficulty communicating with the exogenous, task-positive, executive control network. Together, these findings further articulate the cognitive control dysfunction associated with smoking and illustrate a specific brain circuit potentially responsible.
2015
Fedota, John R; Stein, Elliot A
Resting-state functional connectivity and nicotine addiction: prospects for biomarker development. Journal Article
In: Ann N Y Acad Sci, vol. 1349, pp. 64–82, 2015, ISSN: 1749-6632 (Electronic); 0077-8923 (Linking).
@article{Fedota2015,
title = {Resting-state functional connectivity and nicotine addiction: prospects for biomarker development.},
author = {John R Fedota and Elliot A Stein},
url = {https://www.ncbi.nlm.nih.gov/pubmed/26348486},
doi = {10.1111/nyas.12882},
issn = {1749-6632 (Electronic); 0077-8923 (Linking)},
year = {2015},
date = {2015-09-01},
journal = {Ann N Y Acad Sci},
volume = {1349},
pages = {64--82},
address = {Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland.},
abstract = {Given conceptual frameworks of addiction as a disease of intercommunicating brain networks, examinations of network interactions may provide a holistic characterization of addiction-related dysfunction. One such methodological approach is the examination of resting-state functional connectivity, which quantifies correlations in low-frequency fluctuations of the blood oxygen level-dependent magnetic resonance imaging signal between disparate brain regions in the absence of task performance. Here, evidence of differentiated effects of chronic nicotine exposure, which reduces the efficiency of network communication across the brain, and acute nicotine exposure, which increases connectivity within specific limbic circuits, is discussed. Several large-scale resting networks, including the salience, default, and executive control networks, have also been implicated in nicotine addiction. The dynamics of connectivity changes among and between these large-scale networks during nicotine withdrawal and satiety provide a heuristic framework with which to characterize the neurobiological mechanism of addiction. The ability to simultaneously quantify effects of both chronic (trait) and acute (state) nicotine exposure provides a platform to develop a neuroimaging-based addiction biomarker. While such development remains in its early stages, evidence of coherent modulations in resting-state functional connectivity at various stages of nicotine addiction suggests potential network interactions on which to focus future addiction biomarker development.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Given conceptual frameworks of addiction as a disease of intercommunicating brain networks, examinations of network interactions may provide a holistic characterization of addiction-related dysfunction. One such methodological approach is the examination of resting-state functional connectivity, which quantifies correlations in low-frequency fluctuations of the blood oxygen level-dependent magnetic resonance imaging signal between disparate brain regions in the absence of task performance. Here, evidence of differentiated effects of chronic nicotine exposure, which reduces the efficiency of network communication across the brain, and acute nicotine exposure, which increases connectivity within specific limbic circuits, is discussed. Several large-scale resting networks, including the salience, default, and executive control networks, have also been implicated in nicotine addiction. The dynamics of connectivity changes among and between these large-scale networks during nicotine withdrawal and satiety provide a heuristic framework with which to characterize the neurobiological mechanism of addiction. The ability to simultaneously quantify effects of both chronic (trait) and acute (state) nicotine exposure provides a platform to develop a neuroimaging-based addiction biomarker. While such development remains in its early stages, evidence of coherent modulations in resting-state functional connectivity at various stages of nicotine addiction suggests potential network interactions on which to focus future addiction biomarker development.
Fedota, John R; Sutherland, Matthew T; Salmeron, Betty Jo; Ross, Thomas J; Hong, Elliot L; Stein, Elliot A
Reward Anticipation Is Differentially Modulated by Varenicline and Nicotine in Smokers. Journal Article
In: Neuropsychopharmacology, vol. 40, no. 8, pp. 2038–2046, 2015, ISSN: 1740-634X (Electronic); 0893-133X (Linking).
@article{Fedota2015b,
title = {Reward Anticipation Is Differentially Modulated by Varenicline and Nicotine in Smokers.},
author = {John R Fedota and Matthew T Sutherland and Betty Jo Salmeron and Thomas J Ross and Elliot L Hong and Elliot A Stein},
url = {https://www.ncbi.nlm.nih.gov/pubmed/25742873},
doi = {10.1038/npp.2015.54},
issn = {1740-634X (Electronic); 0893-133X (Linking)},
year = {2015},
date = {2015-03-06},
urldate = {2015-03-06},
journal = {Neuropsychopharmacology},
volume = {40},
number = {8},
pages = {2038--2046},
address = {Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.},
abstract = {Recidivism rates for cigarette smokers following treatment often exceed 80%. Varenicline is the most efficacious pharmacotherapy currently available with cessation rates of 25-35% following a year of treatment. Although the in vivo binding properties are well known, varenicline's neurobiological mechanisms of action are still poorly understood. Varenicline acts as a nicotinic receptor partial agonist or antagonist depending on the presence or absence of nicotine and has been implicated in the reduction of reward signaling more broadly. The current study probed anticipatory reward processing using a revised monetary incentive delay task during fMRI in cohorts of smokers and non-smokers who completed a two-drug, placebo-controlled, double-blind crossover study. All participants underwent ~17 days of order-balanced varenicline and placebo pill administration and were scanned under each condition wearing a transdermal nicotine or placebo patch. Consistent with nicotine's ability to enhance the rewarding properties of nondrug stimuli, acute nicotine administration enhanced activation in response to reward-predicting monetary cues in both smokers and non-smokers. In contrast, varenicline reduced gain magnitude processing, but did so only in smokers. These results suggest that varenicline's downregulation of anticipatory reward processing in smokers, in addition to its previously demonstrated reduction in the negative affect associated with withdrawal, independently and additively alter distinct brain circuits. These effects likely contribute to varenicline's efficacy as a pharmacotherapy for smoking cessation.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Recidivism rates for cigarette smokers following treatment often exceed 80%. Varenicline is the most efficacious pharmacotherapy currently available with cessation rates of 25-35% following a year of treatment. Although the in vivo binding properties are well known, varenicline's neurobiological mechanisms of action are still poorly understood. Varenicline acts as a nicotinic receptor partial agonist or antagonist depending on the presence or absence of nicotine and has been implicated in the reduction of reward signaling more broadly. The current study probed anticipatory reward processing using a revised monetary incentive delay task during fMRI in cohorts of smokers and non-smokers who completed a two-drug, placebo-controlled, double-blind crossover study. All participants underwent ~17 days of order-balanced varenicline and placebo pill administration and were scanned under each condition wearing a transdermal nicotine or placebo patch. Consistent with nicotine's ability to enhance the rewarding properties of nondrug stimuli, acute nicotine administration enhanced activation in response to reward-predicting monetary cues in both smokers and non-smokers. In contrast, varenicline reduced gain magnitude processing, but did so only in smokers. These results suggest that varenicline's downregulation of anticipatory reward processing in smokers, in addition to its previously demonstrated reduction in the negative affect associated with withdrawal, independently and additively alter distinct brain circuits. These effects likely contribute to varenicline's efficacy as a pharmacotherapy for smoking cessation.
2014
Buzzell, George A; Fedota, John R; Roberts, Daniel M; McDonald, Craig G
The N2 ERP component as an index of impaired cognitive control in smokers. Journal Article
In: Neurosci Lett, vol. 563, pp. 61–65, 2014, ISSN: 1872-7972 (Electronic); 0304-3940 (Linking).
@article{Buzzell2014,
title = {The N2 ERP component as an index of impaired cognitive control in smokers.},
author = {George A Buzzell and John R Fedota and Daniel M Roberts and Craig G McDonald},
url = {https://www.ncbi.nlm.nih.gov/pubmed/24486891},
doi = {10.1016/j.neulet.2014.01.030},
issn = {1872-7972 (Electronic); 0304-3940 (Linking)},
year = {2014},
date = {2014-01-30},
journal = {Neurosci Lett},
volume = {563},
pages = {61--65},
address = {George Mason University, Fairfax, VA, USA. Electronic address: gbuzzellchar64gmu.edu.},
abstract = {Impaired cognitive control has been proposed as a hallmark of nicotine dependence and is thought to arise, in part, from synaptic alterations in anterior cingulate cortex (ACC), a primary component of the dopamine reward pathway. The N2 component of the event-related potential (ERP) appears to index a cognitive control process in paradigms such as the visual go/no-go task. Moreover, as dipole-modeling has suggested that the neural generator of the N2 component can be localized to the ACC, this component may prove useful for investigating impairments of cognitive control in smokers. Given conflicting reports of whether the N2 is reduced in smokers (as compared to non-smoker controls), the current study further examined the suitability of this component as an index for impaired cognitive control in smokers. Smokers and non-smokers performed a visual go/no-go task while electroencephalogram (EEG) was recorded. As predicted, the no-go N2 of smokers was significantly smaller than that of non-smoker controls, while the no-go P3 did not differ between groups. Importantly, behavioral performance (reaction time and accuracy) did not differ between smokers and nonsmokers, which might reflect the low levels of nicotine dependence (assessed by the Fagerstrom test) in our sample. The observed N2 modulation in the absence of behavioral impairments provides evidence for the utility of the N2 component as a sensitive measure of impaired cognitive control in smokers, even in those with low levels of nicotine dependence.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Impaired cognitive control has been proposed as a hallmark of nicotine dependence and is thought to arise, in part, from synaptic alterations in anterior cingulate cortex (ACC), a primary component of the dopamine reward pathway. The N2 component of the event-related potential (ERP) appears to index a cognitive control process in paradigms such as the visual go/no-go task. Moreover, as dipole-modeling has suggested that the neural generator of the N2 component can be localized to the ACC, this component may prove useful for investigating impairments of cognitive control in smokers. Given conflicting reports of whether the N2 is reduced in smokers (as compared to non-smoker controls), the current study further examined the suitability of this component as an index for impaired cognitive control in smokers. Smokers and non-smokers performed a visual go/no-go task while electroencephalogram (EEG) was recorded. As predicted, the no-go N2 of smokers was significantly smaller than that of non-smoker controls, while the no-go P3 did not differ between groups. Importantly, behavioral performance (reaction time and accuracy) did not differ between smokers and nonsmokers, which might reflect the low levels of nicotine dependence (assessed by the Fagerstrom test) in our sample. The observed N2 modulation in the absence of behavioral impairments provides evidence for the utility of the N2 component as a sensitive measure of impaired cognitive control in smokers, even in those with low levels of nicotine dependence.
Fedota, John R; Hardee, Jillian E; Perez-Edgar, Koraly; Thompson, James C
Representation of response alternatives in human presupplementary motor area: multi-voxel pattern analysis in a go/no-go task. Journal Article
In: Neuropsychologia, vol. 56, pp. 110–118, 2014, ISSN: 1873-3514 (Electronic); 0028-3932 (Linking).
@article{Fedota2014,
title = {Representation of response alternatives in human presupplementary motor area: multi-voxel pattern analysis in a go/no-go task.},
author = {John R Fedota and Jillian E Hardee and Koraly Perez-Edgar and James C Thompson},
url = {https://www.ncbi.nlm.nih.gov/pubmed/24440411},
doi = {10.1016/j.neuropsychologia.2013.12.022},
issn = {1873-3514 (Electronic); 0028-3932 (Linking)},
year = {2014},
date = {2014-01-15},
journal = {Neuropsychologia},
volume = {56},
pages = {110--118},
address = {Department of Psychology, George Mason University.},
abstract = {A debate exists as to the role of the presupplementary motor area (preSMA) in cognitive control. Recent findings suggest that preSMA plays a central role in conflict resolution and encodes response alternatives as opposed to simply the presence of conflict. Evidence of neuronal heterogeneity within preSMA of non-human primates suggests that univariate analysis of functional MRI data may not provide adequate resolution to fully characterize cognitive control-related responses. Here, multi-voxel pattern analysis (MVPA) is employed to examine the distributed patterns of activity in preSMA associated with both successful go responses and no-go inhibitions. In a go/no-go task, univariate analysis showed undifferentiated activation of preSMA in response to both go and no-go stimuli. However, when an anatomically-defined preSMA ROI was subjected to MVPA, a significant difference in the activation pattern encoded by go as compared to no-go stimuli was observed. These differences in preSMA activation are consistent with the ongoing maintenance and manipulation of stimulus-action representations.},
keywords = {},
pubstate = {published},
tppubtype = {article}
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A debate exists as to the role of the presupplementary motor area (preSMA) in cognitive control. Recent findings suggest that preSMA plays a central role in conflict resolution and encodes response alternatives as opposed to simply the presence of conflict. Evidence of neuronal heterogeneity within preSMA of non-human primates suggests that univariate analysis of functional MRI data may not provide adequate resolution to fully characterize cognitive control-related responses. Here, multi-voxel pattern analysis (MVPA) is employed to examine the distributed patterns of activity in preSMA associated with both successful go responses and no-go inhibitions. In a go/no-go task, univariate analysis showed undifferentiated activation of preSMA in response to both go and no-go stimuli. However, when an anatomically-defined preSMA ROI was subjected to MVPA, a significant difference in the activation pattern encoded by go as compared to no-go stimuli was observed. These differences in preSMA activation are consistent with the ongoing maintenance and manipulation of stimulus-action representations.
Roberts, Daniel M; Fedota, John R; Buzzell, George A; Parasuraman, Raja; McDonald, Craig G
In: J Cogn Neurosci, vol. 26, no. 8, pp. 1615–1628, 2014, ISSN: 1530-8898 (Electronic); 0898-929X (Linking).
@article{Roberts2014,
title = {Prestimulus oscillations in the alpha band of the EEG are modulated by the difficulty of feature discrimination and predict activation of a sensory discrimination process.},
author = {Daniel M Roberts and John R Fedota and George A Buzzell and Raja Parasuraman and Craig G McDonald},
url = {https://www.ncbi.nlm.nih.gov/pubmed/24405187},
doi = {10.1162/jocn_a_00569},
issn = {1530-8898 (Electronic); 0898-929X (Linking)},
year = {2014},
date = {2014-01-09},
journal = {J Cogn Neurosci},
volume = {26},
number = {8},
pages = {1615--1628},
address = {George Mason University, Fairfax, VA.},
abstract = {Recent work has demonstrated that the occipital-temporal N1 component of the ERP is sensitive to the difficulty of visual discrimination, in a manner that cannot be explained by simple differences in low-level visual features, arousal, or time on task. These observations provide evidence that the occipital-temporal N1 component is modulated by the application of top-down control. However, the timing of this control process remains unclear. Previous work has demonstrated proactive, top-down modulation of cortical excitability for cued spatial attention or feature selection tasks. Here, the possibility that a similar top-down process facilitates performance of a difficult stimulus discrimination task is explored. Participants performed an oddball task at two levels of discrimination difficulty, with difficulty manipulated by modulating the similarity between target and nontarget stimuli. Discrimination processes and cortical excitability were assessed via the amplitude of the occipital-temporal N1 component and prestimulus alpha oscillation of the EEG, respectively. For correct discriminations, prestimulus alpha power was reduced, and the occipital-temporal N1 was enhanced in the hard relative to the easy condition. Furthermore, within the hard condition, prestimulus alpha power was reduced, and the occipital-temporal N1 was enhanced for correct relative to incorrect discriminations. The generation of ERPs contingent on relative prestimulus alpha power additionally suggests that diminished alpha power preceding stimulus onset is related to enhancement of the occipital-temporal N1. As in spatial attention, proactive control appears to enhance cortical excitability and facilitate discrimination performance in tasks requiring nonspatial, feature-based attention, even in the absence of competing stimulus features.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Recent work has demonstrated that the occipital-temporal N1 component of the ERP is sensitive to the difficulty of visual discrimination, in a manner that cannot be explained by simple differences in low-level visual features, arousal, or time on task. These observations provide evidence that the occipital-temporal N1 component is modulated by the application of top-down control. However, the timing of this control process remains unclear. Previous work has demonstrated proactive, top-down modulation of cortical excitability for cued spatial attention or feature selection tasks. Here, the possibility that a similar top-down process facilitates performance of a difficult stimulus discrimination task is explored. Participants performed an oddball task at two levels of discrimination difficulty, with difficulty manipulated by modulating the similarity between target and nontarget stimuli. Discrimination processes and cortical excitability were assessed via the amplitude of the occipital-temporal N1 component and prestimulus alpha oscillation of the EEG, respectively. For correct discriminations, prestimulus alpha power was reduced, and the occipital-temporal N1 was enhanced in the hard relative to the easy condition. Furthermore, within the hard condition, prestimulus alpha power was reduced, and the occipital-temporal N1 was enhanced for correct relative to incorrect discriminations. The generation of ERPs contingent on relative prestimulus alpha power additionally suggests that diminished alpha power preceding stimulus onset is related to enhancement of the occipital-temporal N1. As in spatial attention, proactive control appears to enhance cortical excitability and facilitate discrimination performance in tasks requiring nonspatial, feature-based attention, even in the absence of competing stimulus features.
2012
Fedota, John R; McDonald, Craig G; Roberts, Daniel M; Parasuraman, Raja
In: Psychophysiology, vol. 49, no. 10, pp. 1384–1393, 2012, ISSN: 1540-5958 (Electronic); 0048-5772 (Linking).
@article{Fedota2012,
title = {Contextual task difficulty modulates stimulus discrimination: electrophysiological evidence for interaction between sensory and executive processes.},
author = {John R Fedota and Craig G McDonald and Daniel M Roberts and Raja Parasuraman},
url = {https://www.ncbi.nlm.nih.gov/pubmed/22906001},
doi = {10.1111/j.1469-8986.2012.01455.x},
issn = {1540-5958 (Electronic); 0048-5772 (Linking)},
year = {2012},
date = {2012-08-20},
journal = {Psychophysiology},
volume = {49},
number = {10},
pages = {1384--1393},
address = {Department of Psychology, George Mason University, Fairfax, Virginia, USA. jfedota@gmu.edu},
abstract = {The occipital-temporal N1 component of the event-related potential (ERP) has previously been shown to index a stimulus discrimination process. However, the N1 has not consistently been shown to be sensitive to the difficulty of stimulus discrimination. Here, we manipulated the difficulty of stimulus discrimination by modulating the similarity between serially presented targets and nontargets. The same target stimulus was employed in both easy and difficult discrimination contexts, and these physically identical target stimuli elicited a larger N1 and smaller P3b in the difficult task context. Moreover, when targets were incorrectly categorized, N1 amplitude was diminished and a P3b was not elicited. These findings provide evidence that the N1 component reflects a sensory discrimination process that is modulated by executive control, and that this component can index discrimination errors when stimulus discrimination is difficult.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The occipital-temporal N1 component of the event-related potential (ERP) has previously been shown to index a stimulus discrimination process. However, the N1 has not consistently been shown to be sensitive to the difficulty of stimulus discrimination. Here, we manipulated the difficulty of stimulus discrimination by modulating the similarity between serially presented targets and nontargets. The same target stimulus was employed in both easy and difficult discrimination contexts, and these physically identical target stimuli elicited a larger N1 and smaller P3b in the difficult task context. Moreover, when targets were incorrectly categorized, N1 amplitude was diminished and a P3b was not elicited. These findings provide evidence that the N1 component reflects a sensory discrimination process that is modulated by executive control, and that this component can index discrimination errors when stimulus discrimination is difficult.
Fu, Shimin; Fedota, John R; Greenwood, Pamela M; Parasuraman, Raja
Attentional load is not a critical factor for eliciting C1 attentional effect -- A reply to Rauss, Pourtois, Vuilleumier, and Schwartz Journal Article
In: Biological Psychology, vol. 91, no. 2, pp. 321 - 324, 2012, ISSN: 0301-0511.
@article{FU2012321,
title = {Attentional load is not a critical factor for eliciting C1 attentional effect -- A reply to Rauss, Pourtois, Vuilleumier, and Schwartz},
author = {Shimin Fu and John R Fedota and Pamela M Greenwood and Raja Parasuraman},
url = {http://www.sciencedirect.com/science/article/pii/S0301051112000749},
doi = {https://doi.org/10.1016/j.biopsycho.2012.03.012},
issn = {0301-0511},
year = {2012},
date = {2012-01-01},
journal = {Biological Psychology},
volume = {91},
number = {2},
pages = {321 - 324},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2010
Fu, Shimin; Fedota, John R; Greenwood, Pamela M; Parasuraman, Raja
Dissociation of visual C1 and P1 components as a function of attentional load: an event-related potential study. Journal Article
In: Biol Psychol, vol. 85, no. 1, pp. 171–178, 2010, ISSN: 1873-6246 (Electronic); 0301-0511 (Linking).
@article{Fu2010,
title = {Dissociation of visual C1 and P1 components as a function of attentional load: an event-related potential study.},
author = {Shimin Fu and John R Fedota and Pamela M Greenwood and Raja Parasuraman},
url = {https://www.ncbi.nlm.nih.gov/pubmed/20599467},
doi = {10.1016/j.biopsycho.2010.06.008},
issn = {1873-6246 (Electronic); 0301-0511 (Linking)},
year = {2010},
date = {2010-07-03},
journal = {Biol Psychol},
volume = {85},
number = {1},
pages = {171--178},
address = {Department of Psychology, Tsinghua University, Haidan, Beijing, China. sfu@tsinghua.edu.cn},
abstract = {The earliest cortical location at which attention influences visual processing is controversial. To address this issue, the C1 and P1 components of cue-elicited ERPs were examined in a spatially-cued task under high and low levels of attentional load (active vs. passive viewing). Cues were presented either to the left or to the right visual field in separate trials (unilateral presentation), or to both visual fields simultaneously (bilateral presentation). For the unilateral presentation, C1 (peak latency approximately 80 ms) was not modulated by attentional load, whereas P1 (peak latency approximately 120-140 ms) was larger for high-relative to low-load condition. Bilateral presentation of the stimuli enhanced the amplitude of the C1 component relative to unilateral presentation; however, the increase of signal/noise ratio of C1 revealed no attentional load effect on C1. Results show that attentional load modulates visual processing in the P1, but not in the C1 time range, regardless of the increased signal/noise ratio by bilateral presentation. While it remains unclear about the conditions under which a C1 attentional effect is reliably elicited, the present results suggest that the direct manipulation of attentional load under a voluntary attention task seems not crucial for eliciting C1 attentional effect.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The earliest cortical location at which attention influences visual processing is controversial. To address this issue, the C1 and P1 components of cue-elicited ERPs were examined in a spatially-cued task under high and low levels of attentional load (active vs. passive viewing). Cues were presented either to the left or to the right visual field in separate trials (unilateral presentation), or to both visual fields simultaneously (bilateral presentation). For the unilateral presentation, C1 (peak latency approximately 80 ms) was not modulated by attentional load, whereas P1 (peak latency approximately 120-140 ms) was larger for high-relative to low-load condition. Bilateral presentation of the stimuli enhanced the amplitude of the C1 component relative to unilateral presentation; however, the increase of signal/noise ratio of C1 revealed no attentional load effect on C1. Results show that attentional load modulates visual processing in the P1, but not in the C1 time range, regardless of the increased signal/noise ratio by bilateral presentation. While it remains unclear about the conditions under which a C1 attentional effect is reliably elicited, the present results suggest that the direct manipulation of attentional load under a voluntary attention task seems not crucial for eliciting C1 attentional effect.
2009
Fu, Shimin; Fedota, John; Greenwood, Pamela M; Parasuraman, Raja
Early interaction between perceptual load and involuntary attention: An event-related potential study. Journal Article
In: Neurosci Lett, vol. 468, no. 1, pp. 68–71, 2009, ISSN: 1872-7972 (Electronic); 0304-3940 (Linking).
@article{Fu2009,
title = {Early interaction between perceptual load and involuntary attention: An event-related potential study.},
author = {Shimin Fu and John Fedota and Pamela M Greenwood and Raja Parasuraman},
url = {https://www.ncbi.nlm.nih.gov/pubmed/19874869},
doi = {10.1016/j.neulet.2009.10.065},
issn = {1872-7972 (Electronic); 0304-3940 (Linking)},
year = {2009},
date = {2009-10-27},
journal = {Neurosci Lett},
volume = {468},
number = {1},
pages = {68--71},
address = {ARCH Laboratory, Department of Psychology, George Mason University, Fairfax, VA 22030-4444, USA. shimin.fu@gmail.com},
abstract = {Whether selective attention affects C1, the first (earliest) visual cortical component of the event-related potential (ERP), remains controversial. We used a cued, involuntary attention task requiring discrimination of targets under low and high levels of perceptual load to examine early attentional modulation in visual cortex. Potential confounds due to physical stimulus differences between load conditions and cue-target sensory interaction were minimized. An interaction between perceptual load and involuntary attention was observed for the P1m component (peak latency between 100 and 140 ms). Furthermore, the parieto-central C1 component (peak latency 80 ms) was modulated by attention, but only under the high-load condition. Thus, whereas attention typically modulates the later P1 component, attentional modulation of C1 is possible under optimal conditions. Specifically, a high perceptual load is necessary for eliciting this earliest attentional effect on cortical processing.},
keywords = {},
pubstate = {published},
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Whether selective attention affects C1, the first (earliest) visual cortical component of the event-related potential (ERP), remains controversial. We used a cued, involuntary attention task requiring discrimination of targets under low and high levels of perceptual load to examine early attentional modulation in visual cortex. Potential confounds due to physical stimulus differences between load conditions and cue-target sensory interaction were minimized. An interaction between perceptual load and involuntary attention was observed for the P1m component (peak latency between 100 and 140 ms). Furthermore, the parieto-central C1 component (peak latency 80 ms) was modulated by attention, but only under the high-load condition. Thus, whereas attention typically modulates the later P1 component, attentional modulation of C1 is possible under optimal conditions. Specifically, a high perceptual load is necessary for eliciting this earliest attentional effect on cortical processing.
