Contact
Biomedical Research Center251 Bayview Boulevard
Baltimore, MD 21224
Education
Ph.D. - Beijing Normal University of China
Research Interests
In 2012, she received her Ph.D. in the State Key Laboratory of Cognitive Neurosciences and Learning in Beijing Normal University of China. Her main work during the Ph.D. program was to combine resting state fMRI and task state fMRI to explore the gene effect in healthy controls and depression patients. She joined the Neuroimaging Research Branch at NIDA in August 2012 as a post-doctoral visiting fellow under Dr. Yihong Yang.
The general goal of her research is to explore the gene effects on drug abuse’s brain mechanisms using multi-modality MRI techniques including resting-state fMRI and perfusion MRI. One recent project is trying to combine whole-genome analysis and functional MRI to identify the genetic mechanism of drug addiction.
Publications
Selected Publications
2012
Wang, De-Yi; Han, Xiu-Jie; Li, Su-Fang; Liu, Dong-Qiang; Yan, Chao-Gan; Zuo, Xi-Nian; Zhu, Chao-Zhe; He, Yong; Kiviniemi, Vesa; Zang, Yu-Feng
Effects of apolipoprotein E genotype on the off-line memory consolidation. Journal Article
In: PLoS One, vol. 7, no. 12, pp. e51617, 2012, ISSN: 1932-6203 (Electronic); 1932-6203 (Linking).
@article{Wang2012,
title = {Effects of apolipoprotein E genotype on the off-line memory consolidation.},
author = {De-Yi Wang and Xiu-Jie Han and Su-Fang Li and Dong-Qiang Liu and Chao-Gan Yan and Xi-Nian Zuo and Chao-Zhe Zhu and Yong He and Vesa Kiviniemi and Yu-Feng Zang},
url = {https://www.ncbi.nlm.nih.gov/pubmed/23251595},
doi = {10.1371/journal.pone.0051617},
issn = {1932-6203 (Electronic); 1932-6203 (Linking)},
year = {2012},
date = {2012-12-12},
journal = {PLoS One},
volume = {7},
number = {12},
pages = {e51617},
address = {State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.},
abstract = {Spontaneous brain activity or off-line activity after memory encoding is associated with memory consolidation. A few recent resting-state functional magnetic resonance imaging (RS-fMRI) studies indicate that the RS-fMRI could map off-line memory consolidation effects. However, the gene effects on memory consolidation process remain largely unknown. Here we collected two RS-fMRI sessions, one before and another after an episodic memory encoding task, from two groups of healthy young adults, one with apolipoprotein E (APOE) epsilon2/epsilon3 and the other with APOE epsilon3/epsilon4. The ratio of regional homogeneity (ReHo), a measure of local synchronization of spontaneous RS-fMRI signal, of the two sessions was used as an index of memory-consolidation. APOE epsilon3/epsilon4 group showed greater ReHo ratio within the medial temporal lobe (MTL). The ReHo ratio in MTL was significantly correlated with the recognition memory performance in the APOE epsilon3/epsilon4 group but not in epsilon2/epsilon3 group. Additionally, APOE epsilon3/epsilon4 group showed lower ReHo ratio in the occipital and parietal picture-encoding areas. Our results indicate that APOE epsilon3/epsilon4 group may have a different off-line memory consolidation process compared to epsilon2/epsilon3 group. These results may help generate future hypotheses that the off-line memory consolidation might be impaired in Alzheimer's disease.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Spontaneous brain activity or off-line activity after memory encoding is associated with memory consolidation. A few recent resting-state functional magnetic resonance imaging (RS-fMRI) studies indicate that the RS-fMRI could map off-line memory consolidation effects. However, the gene effects on memory consolidation process remain largely unknown. Here we collected two RS-fMRI sessions, one before and another after an episodic memory encoding task, from two groups of healthy young adults, one with apolipoprotein E (APOE) epsilon2/epsilon3 and the other with APOE epsilon3/epsilon4. The ratio of regional homogeneity (ReHo), a measure of local synchronization of spontaneous RS-fMRI signal, of the two sessions was used as an index of memory-consolidation. APOE epsilon3/epsilon4 group showed greater ReHo ratio within the medial temporal lobe (MTL). The ReHo ratio in MTL was significantly correlated with the recognition memory performance in the APOE epsilon3/epsilon4 group but not in epsilon2/epsilon3 group. Additionally, APOE epsilon3/epsilon4 group showed lower ReHo ratio in the occipital and parietal picture-encoding areas. Our results indicate that APOE epsilon3/epsilon4 group may have a different off-line memory consolidation process compared to epsilon2/epsilon3 group. These results may help generate future hypotheses that the off-line memory consolidation might be impaired in Alzheimer's disease.
Liu, Chun-Hong; Ma, Xin; Li, Feng; Wang, Yong-Jun; Tie, Chang-Le; Li, Su-Fang; Chen, Tao-Lin; Fan, Ting-ting; Zhang, Yu; Dong, Jie; Yao, Li; Wu, Xia; Wang, Chuan-Yue
Regional homogeneity within the default mode network in bipolar depression: a resting-state functional magnetic resonance imaging study. Journal Article
In: PLoS One, vol. 7, no. 11, pp. e48181, 2012, ISSN: 1932-6203 (Electronic); 1932-6203 (Linking).
@article{Liu2012b,
title = {Regional homogeneity within the default mode network in bipolar depression: a resting-state functional magnetic resonance imaging study.},
author = {Chun-Hong Liu and Xin Ma and Feng Li and Yong-Jun Wang and Chang-Le Tie and Su-Fang Li and Tao-Lin Chen and Ting-ting Fan and Yu Zhang and Jie Dong and Li Yao and Xia Wu and Chuan-Yue Wang},
url = {https://www.ncbi.nlm.nih.gov/pubmed/23133615},
doi = {10.1371/journal.pone.0048181},
issn = {1932-6203 (Electronic); 1932-6203 (Linking)},
year = {2012},
date = {2012-11-02},
journal = {PLoS One},
volume = {7},
number = {11},
pages = {e48181},
address = {Department of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China.},
abstract = {AIM: We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD). METHODS: Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences. RESULTS: Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group. CONCLUSIONS: Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
AIM: We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD). METHODS: Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences. RESULTS: Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group. CONCLUSIONS: Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression.
Wang, De-Yi; Liu, Dong-Qiang; Li, Su-Fang; Zang, Yu-Feng
Increased local synchronization of resting-state fMRI signal after episodic memory encoding reflects off-line memory consolidation. Journal Article
In: Neuroreport, vol. 23, no. 15, pp. 873–878, 2012, ISSN: 1473-558X (Electronic); 0959-4965 (Linking).
@article{Wang2012b,
title = {Increased local synchronization of resting-state fMRI signal after episodic memory encoding reflects off-line memory consolidation.},
author = {De-Yi Wang and Dong-Qiang Liu and Su-Fang Li and Yu-Feng Zang},
url = {https://www.ncbi.nlm.nih.gov/pubmed/22955145},
doi = {10.1097/WNR.0b013e3283587c96},
issn = {1473-558X (Electronic); 0959-4965 (Linking)},
year = {2012},
date = {2012-10-24},
journal = {Neuroreport},
volume = {23},
number = {15},
pages = {873--878},
address = {State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.},
abstract = {The changes of spontaneous activity from before and after a memory or learning task had been considered to be related to off-line memory consolidation process in human brain by using resting-state functional connectivity (RSFC) MRI (fMRI). However, RSFC reflects temporal synchronization of timecourses of spatially distinct brain regions and therefore could not determine which specific brain region is involved in the memory consolidation process. Here we used regional homogeneity (ReHo), a method for measuring local synchronization, to link the local spontaneous activity change to off-line episodic memory consolidation. We hypothesized that the spontaneous activity change would be different between people with better memory performance and those with worse performance in memory-related regions. All participants completed two resting-state sessions, that is, before (REST-1) and after (REST-2) an episodic memory encoding task (picture indoor or outdoor judgment). Then, based on the d' of a later surprise memory retrieval test, a high-performance group and a low-performance group, each consisting of 16 participants, were chosen from whole 58 participants. We defined a ReHo ratio, that is, ReHo of REST-2 divided by ReHo of REST-1, as a change induced by memory consolidation. The high-performance group showed a significant higher ReHo ratio than low-performance group in medial temporal lobe (MTL) including parahippocampal and anterior temporal regions. The current results provide neuroimaging evidence supporting that the MTL is involved in off-line memory consolidation of episodic memory. Moreover, this study may provide a paradigm for understanding of episodic memory deficit in Alzheimer's disease.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The changes of spontaneous activity from before and after a memory or learning task had been considered to be related to off-line memory consolidation process in human brain by using resting-state functional connectivity (RSFC) MRI (fMRI). However, RSFC reflects temporal synchronization of timecourses of spatially distinct brain regions and therefore could not determine which specific brain region is involved in the memory consolidation process. Here we used regional homogeneity (ReHo), a method for measuring local synchronization, to link the local spontaneous activity change to off-line episodic memory consolidation. We hypothesized that the spontaneous activity change would be different between people with better memory performance and those with worse performance in memory-related regions. All participants completed two resting-state sessions, that is, before (REST-1) and after (REST-2) an episodic memory encoding task (picture indoor or outdoor judgment). Then, based on the d' of a later surprise memory retrieval test, a high-performance group and a low-performance group, each consisting of 16 participants, were chosen from whole 58 participants. We defined a ReHo ratio, that is, ReHo of REST-2 divided by ReHo of REST-1, as a change induced by memory consolidation. The high-performance group showed a significant higher ReHo ratio than low-performance group in medial temporal lobe (MTL) including parahippocampal and anterior temporal regions. The current results provide neuroimaging evidence supporting that the MTL is involved in off-line memory consolidation of episodic memory. Moreover, this study may provide a paradigm for understanding of episodic memory deficit in Alzheimer's disease.
Liu, Chun-Hong; Li, Feng; Li, Su-Fang; Wang, Yong-Jun; Tie, Chang-Le; Wu, Hai-Yan; Zhou, Zhen; Zhang, Dan; Dong, Jie; Yang, Zhi; Wang, Chuan-Yue
Abnormal baseline brain activity in bipolar depression: a resting state functional magnetic resonance imaging study. Journal Article
In: Psychiatry Res, vol. 203, no. 2-3, pp. 175–179, 2012, ISSN: 1872-7123 (Electronic); 0165-1781 (Linking).
@article{Liu2012,
title = {Abnormal baseline brain activity in bipolar depression: a resting state functional magnetic resonance imaging study.},
author = {Chun-Hong Liu and Feng Li and Su-Fang Li and Yong-Jun Wang and Chang-Le Tie and Hai-Yan Wu and Zhen Zhou and Dan Zhang and Jie Dong and Zhi Yang and Chuan-Yue Wang},
url = {https://www.ncbi.nlm.nih.gov/pubmed/23017873},
doi = {10.1016/j.pscychresns.2012.02.007},
issn = {1872-7123 (Electronic); 0165-1781 (Linking)},
year = {2012},
date = {2012-09-25},
journal = {Psychiatry Res},
volume = {203},
number = {2-3},
pages = {175--179},
address = {Department of Radiology, Capital Medical University, Beijing, China.},
abstract = {We examined resting state brain activity in the depressive phase of bipolar disorder (BD) by measuring the amplitude of low-frequency fluctuations (ALFF) in the functional magnetic resonance imaging (fMRI) signal. Unlike functional connectivity, the ALFF approach reflects local properties in specific regions and provides direct information about impaired foci. Groups of 26 patients with BD depression and 26 gender-, age-, and education-matched healthy subjects participated in fMRI scans. We examined group differences in ALFF findings as well as correlations between clinical measurements and ALFF in the regions showing significant group differences. Our results showed that patients with BD depression had significantly increased ALFF in the left insula, the right caudate nucleus, the temporal gyrus, the bilateral inferior frontal gyrus, and the posterior lobe of the cerebellum. They also had decreased ALFF in the left postcentral gyrus, the left parahippocampal gyrus, and the cerebellum. Moderate negative correlations were found between the Hamilton Depression Rating Scale score and ALFF in the left insular cortex in the patient group. These results support a model of BD that involves dysfunction in the prefrontal-limbic networks and associated striatal systems. We also demonstrated the feasibility of ALFF as a technique to investigate persistent cerebral dysfunction in BD.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
We examined resting state brain activity in the depressive phase of bipolar disorder (BD) by measuring the amplitude of low-frequency fluctuations (ALFF) in the functional magnetic resonance imaging (fMRI) signal. Unlike functional connectivity, the ALFF approach reflects local properties in specific regions and provides direct information about impaired foci. Groups of 26 patients with BD depression and 26 gender-, age-, and education-matched healthy subjects participated in fMRI scans. We examined group differences in ALFF findings as well as correlations between clinical measurements and ALFF in the regions showing significant group differences. Our results showed that patients with BD depression had significantly increased ALFF in the left insula, the right caudate nucleus, the temporal gyrus, the bilateral inferior frontal gyrus, and the posterior lobe of the cerebellum. They also had decreased ALFF in the left postcentral gyrus, the left parahippocampal gyrus, and the cerebellum. Moderate negative correlations were found between the Hamilton Depression Rating Scale score and ALFF in the left insular cortex in the patient group. These results support a model of BD that involves dysfunction in the prefrontal-limbic networks and associated striatal systems. We also demonstrated the feasibility of ALFF as a technique to investigate persistent cerebral dysfunction in BD.
Li, Ping; Li, Sufang; Dong, Zhangye; Luo, Jia; Han, Haiying; Xiong, Hongfang; Guo, Zhihua; Li, Zhanjiang
Altered resting state functional connectivity patterns of the anterior prefrontal cortex in obsessive-compulsive disorder. Journal Article
In: Neuroreport, vol. 23, no. 11, pp. 681–686, 2012, ISSN: 1473-558X (Electronic); 0959-4965 (Linking).
@article{Li2012d,
title = {Altered resting state functional connectivity patterns of the anterior prefrontal cortex in obsessive-compulsive disorder.},
author = {Ping Li and Sufang Li and Zhangye Dong and Jia Luo and Haiying Han and Hongfang Xiong and Zhihua Guo and Zhanjiang Li},
url = {https://www.ncbi.nlm.nih.gov/pubmed/22692554},
doi = {10.1097/WNR.0b013e328355a5fe},
issn = {1473-558X (Electronic); 0959-4965 (Linking)},
year = {2012},
date = {2012-08-01},
journal = {Neuroreport},
volume = {23},
number = {11},
pages = {681--686},
address = {Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, China.},
abstract = {In this study, we explored different spontaneous functional connectivity patterns between the anterior prefrontal cortex and other brain regions in nonmedicated patients with obsessive-compulsive disorder in a resting state, and examined the relationship between the abnormal spontaneous functional connectivity patterns of the anterior prefrontal cortex and clinical symptoms in patients with obsessive-compulsive disorder. Twenty nonmedicated patients with obsessive-compulsive disorder and 20 sex-matched and age-matched healthy individuals underwent resting state functional MRI scanning. Compared with the healthy controls, significantly increased positive functional connectivity with the right anterior prefrontal cortex was observed in the right insula and the middle cingulate cortex in patients with obsessive-compulsive disorder. Our findings suggest that abnormal intrinsic or spontaneous functional connectivity in the cognitive control system in a resting state may underlie the pathophysiology of obsessive-compulsive disorder.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
In this study, we explored different spontaneous functional connectivity patterns between the anterior prefrontal cortex and other brain regions in nonmedicated patients with obsessive-compulsive disorder in a resting state, and examined the relationship between the abnormal spontaneous functional connectivity patterns of the anterior prefrontal cortex and clinical symptoms in patients with obsessive-compulsive disorder. Twenty nonmedicated patients with obsessive-compulsive disorder and 20 sex-matched and age-matched healthy individuals underwent resting state functional MRI scanning. Compared with the healthy controls, significantly increased positive functional connectivity with the right anterior prefrontal cortex was observed in the right insula and the middle cingulate cortex in patients with obsessive-compulsive disorder. Our findings suggest that abnormal intrinsic or spontaneous functional connectivity in the cognitive control system in a resting state may underlie the pathophysiology of obsessive-compulsive disorder.
Li, Sufang; Zou, Qihong; Li, Jun; Li, Jin; Wang, Deyi; Yan, Chaogan; Dong, Qi; Zang, Yu-Feng
5-HTTLPR polymorphism impacts task-evoked and resting-state activities of the amygdala in Han Chinese. Journal Article
In: PLoS One, vol. 7, no. 5, pp. e36513, 2012, ISSN: 1932-6203 (Electronic); 1932-6203 (Linking).
@article{Li2012c,
title = {5-HTTLPR polymorphism impacts task-evoked and resting-state activities of the amygdala in Han Chinese.},
author = {Sufang Li and Qihong Zou and Jun Li and Jin Li and Deyi Wang and Chaogan Yan and Qi Dong and Yu-Feng Zang},
url = {https://www.ncbi.nlm.nih.gov/pubmed/22574175},
doi = {10.1371/journal.pone.0036513},
issn = {1932-6203 (Electronic); 1932-6203 (Linking)},
year = {2012},
date = {2012-05-04},
journal = {PLoS One},
volume = {7},
number = {5},
pages = {e36513},
address = {State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.},
abstract = {BACKGROUND: Prior research has shown that the amygdala of carriers of the short allele (s) of the serotonin transporter (5-HTT) gene (5-HTTLPR) have a larger response to negative emotional stimuli and higher spontaneous activity during the resting state than non-carriers. However, recent studies have suggested that the effects of 5-HTTLPR may be specific to different ethnic groups. Few studies have been conducted to address this issue. METHODOLOGY/PRINCIPAL FINDINGS: Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) was conducted on thirty-eight healthy Han Chinese subjects (l/l group},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Prior research has shown that the amygdala of carriers of the short allele (s) of the serotonin transporter (5-HTT) gene (5-HTTLPR) have a larger response to negative emotional stimuli and higher spontaneous activity during the resting state than non-carriers. However, recent studies have suggested that the effects of 5-HTTLPR may be specific to different ethnic groups. Few studies have been conducted to address this issue. METHODOLOGY/PRINCIPAL FINDINGS: Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) was conducted on thirty-eight healthy Han Chinese subjects (l/l group
2011
Song, Xiao-Wei; Dong, Zhang-Ye; Long, Xiang-Yu; Li, Su-Fang; Zuo, Xi-Nian; Zhu, Chao-Zhe; He, Yong; Yan, Chao-Gan; Zang, Yu-Feng
REST: a toolkit for resting-state functional magnetic resonance imaging data processing. Journal Article
In: PLoS One, vol. 6, no. 9, pp. e25031, 2011, ISSN: 1932-6203 (Electronic); 1932-6203 (Linking).
@article{Song2011,
title = {REST: a toolkit for resting-state functional magnetic resonance imaging data processing.},
author = {Xiao-Wei Song and Zhang-Ye Dong and Xiang-Yu Long and Su-Fang Li and Xi-Nian Zuo and Chao-Zhe Zhu and Yong He and Chao-Gan Yan and Yu-Feng Zang},
url = {https://www.ncbi.nlm.nih.gov/pubmed/21949842},
doi = {10.1371/journal.pone.0025031},
issn = {1932-6203 (Electronic); 1932-6203 (Linking)},
year = {2011},
date = {2011-09-20},
journal = {PLoS One},
volume = {6},
number = {9},
pages = {e25031},
address = {State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.},
abstract = {Resting-state fMRI (RS-fMRI) has been drawing more and more attention in recent years. However, a publicly available, systematically integrated and easy-to-use tool for RS-fMRI data processing is still lacking. We developed a toolkit for the analysis of RS-fMRI data, namely the RESting-state fMRI data analysis Toolkit (REST). REST was developed in MATLAB with graphical user interface (GUI). After data preprocessing with SPM or AFNI, a few analytic methods can be performed in REST, including functional connectivity analysis based on linear correlation, regional homogeneity, amplitude of low frequency fluctuation (ALFF), and fractional ALFF. A few additional functions were implemented in REST, including a DICOM sorter, linear trend removal, bandpass filtering, time course extraction, regression of covariates, image calculator, statistical analysis, and slice viewer (for result visualization, multiple comparison correction, etc.). REST is an open-source package and is freely available at http://www.restfmri.net.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Resting-state fMRI (RS-fMRI) has been drawing more and more attention in recent years. However, a publicly available, systematically integrated and easy-to-use tool for RS-fMRI data processing is still lacking. We developed a toolkit for the analysis of RS-fMRI data, namely the RESting-state fMRI data analysis Toolkit (REST). REST was developed in MATLAB with graphical user interface (GUI). After data preprocessing with SPM or AFNI, a few analytic methods can be performed in REST, including functional connectivity analysis based on linear correlation, regional homogeneity, amplitude of low frequency fluctuation (ALFF), and fractional ALFF. A few additional functions were implemented in REST, including a DICOM sorter, linear trend removal, bandpass filtering, time course extraction, regression of covariates, image calculator, statistical analysis, and slice viewer (for result visualization, multiple comparison correction, etc.). REST is an open-source package and is freely available at http://www.restfmri.net.
