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Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway

A figure from this articleReviews To Read – March 2022.

Published in Progress in Neurobiology and Coauthored by Satoshi Ikemoto of the NIDA IRP Neurocircuitry of Motivation Section.

Little is known about neural substrates of curiosity and exploratory behavior. We refer to such behavior as information-seeking behavior and propose 1) key neural substrates and 2) the concept of environment prediction error as a framework to understand information-seeking processes. The cognitive aspect of information-seeking behavior involves, in part, the pathways from the posterior hypothalamic supramammillary region to the hippocampal formation. The vigor of such behavior is modulated by the supramammillo-septo-ventral tegmental pathway. Phasic responses of dopaminergic neurons are characterized as signaling potentially important stimuli rather than rewards. This paper describes how novel stimuli and uncertainty trigger seeking motivation and how these neural substrates modulate information-seeking behavior.

Kesner, Andrew J; Calva, Coleman B; Ikemoto, Satoshi

Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway Journal Article

In: Prog Neurobiol, vol. 212, pp. 102252, 2022, ISSN: 1873-5118.

Abstract | Links

@article{pmid35227866,
title = {Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway},
author = {Andrew J Kesner and Coleman B Calva and Satoshi Ikemoto},
url = {https://pubmed.ncbi.nlm.nih.gov/35227866/},
doi = {10.1016/j.pneurobio.2022.102252},
issn = {1873-5118},
year = {2022},
date = {2022-02-01},
urldate = {2022-02-01},
journal = {Prog Neurobiol},
volume = {212},
pages = {102252},
abstract = {Reinforcement learning and goal-seeking behavior are thought to be mediated by midbrain dopamine neurons. However, little is known about neural substrates of curiosity and exploratory behavior, which occur in the absence of clear goal or reward. This is despite behavioral scientists having long suggested that curiosity and exploratory behaviors are regulated by an innate drive. We refer to such behavior as information-seeking behavior and propose 1) key neural substrates and 2) the concept of environment prediction error as a framework to understand information-seeking processes. The cognitive aspect of information-seeking behavior, including the perception of salience and uncertainty, involves, in part, the pathways from the posterior hypothalamic supramammillary region to the hippocampal formation. The vigor of such behavior is modulated by the following: supramammillary glutamatergic neurons; their projections to medial septal glutamatergic neurons; and the projections of medial septal glutamatergic neurons to ventral tegmental dopaminergic neurons. Phasic responses of dopaminergic neurons are characterized as signaling potentially important stimuli rather than rewards. This paper describes how novel stimuli and uncertainty trigger seeking motivation and how these neural substrates modulate information-seeking behavior.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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Reinforcement learning and goal-seeking behavior are thought to be mediated by midbrain dopamine neurons. However, little is known about neural substrates of curiosity and exploratory behavior, which occur in the absence of clear goal or reward. This is despite behavioral scientists having long suggested that curiosity and exploratory behaviors are regulated by an innate drive. We refer to such behavior as information-seeking behavior and propose 1) key neural substrates and 2) the concept of environment prediction error as a framework to understand information-seeking processes. The cognitive aspect of information-seeking behavior, including the perception of salience and uncertainty, involves, in part, the pathways from the posterior hypothalamic supramammillary region to the hippocampal formation. The vigor of such behavior is modulated by the following: supramammillary glutamatergic neurons; their projections to medial septal glutamatergic neurons; and the projections of medial septal glutamatergic neurons to ventral tegmental dopaminergic neurons. Phasic responses of dopaminergic neurons are characterized as signaling potentially important stimuli rather than rewards. This paper describes how novel stimuli and uncertainty trigger seeking motivation and how these neural substrates modulate information-seeking behavior.

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  • https://pubmed.ncbi.nlm.nih.gov/35227866/
  • doi:10.1016/j.pneurobio.2022.102252

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