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Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine.

A figure from this study.

A figure from this study.

Reviews To Read – March 2019.

Cocaine drives persistent changes in synaptic transmission and ventral tegmental area dopamine neuron activity. Francis et al. reviews how these alterations contribute to cocaine addiction and highlight therapeutic avenues for future treatment.

Francis, Tanner Chase; Gantz, Stephanie C; Moussawi, Khaled; Bonci, Antonello

Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine. Journal Article

In: Curr Opin Neurobiol, vol. 54, pp. 66–72, 2019, ISSN: 1873-6882 (Electronic); 0959-4388 (Linking).

Abstract | Links

@article{Francis:2019aa,
title = {Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine.},
author = {Tanner Chase Francis and Stephanie C Gantz and Khaled Moussawi and Antonello Bonci},
url = {https://www.ncbi.nlm.nih.gov/pubmed/30237117},
doi = {10.1016/j.conb.2018.08.013},
issn = {1873-6882 (Electronic); 0959-4388 (Linking)},
year = {2019},
date = {2019-02-01},
journal = {Curr Opin Neurobiol},
volume = {54},
pages = {66--72},
address = {Intramural Research Program, Synaptic Plasticity Section, National Institute on Drug Abuse, US National Institutes of Health, Baltimore, MD 21224, USA.},
abstract = {Cocaine exposure induces persistent changes in synaptic transmission and intrinsic properties of ventral tegmental area (VTA) dopamine neurons. Despite significant progress in understanding cocaine-induced plasticity, an effective treatment of cocaine addiction is lacking. Chronic cocaine potentiates excitatory and alters inhibitory transmission to dopamine neurons, induces dopamine neuron hyperexcitability, and reduces dopamine release in projection areas. Understanding how intrinsic and synaptic plasticity interact to control dopamine neuron firing and dopamine release could prove useful in the development of new therapeutics. In this review, we examine recent literature discussing cocaine-induced plasticity in the VTA and highlight potential therapeutic interventions.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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Cocaine exposure induces persistent changes in synaptic transmission and intrinsic properties of ventral tegmental area (VTA) dopamine neurons. Despite significant progress in understanding cocaine-induced plasticity, an effective treatment of cocaine addiction is lacking. Chronic cocaine potentiates excitatory and alters inhibitory transmission to dopamine neurons, induces dopamine neuron hyperexcitability, and reduces dopamine release in projection areas. Understanding how intrinsic and synaptic plasticity interact to control dopamine neuron firing and dopamine release could prove useful in the development of new therapeutics. In this review, we examine recent literature discussing cocaine-induced plasticity in the VTA and highlight potential therapeutic interventions.

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  • https://www.ncbi.nlm.nih.gov/pubmed/30237117
  • doi:10.1016/j.conb.2018.08.013

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