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National Institute on Drug Abuse - Intramural Research Program

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Computational Chemistry and Molecular Biophysics Section

Lei Shi, Ph.D.

Lei Shi, Ph.D.

A division of the Molecular Targets and Medications Discovery Branch

Section Chief

Lei Shi, Ph.D.

Contact

Location:
Triad Technology Center
333 Cassell Drive
Room 1121
Baltimore, MD 21224

Phone: 667-312-5284

Email: lei.shi2@nih.gov

Research Interests

Membrane proteins (MP) initiate intracellular signaling pathways, control the flow of energy and materials in and out of the cell, and thereby account for more than 30% of the human proteome and 40% of drug targets. Research interest in the lab is focused on investigating structural basis of MP functions to advance mechanistic understanding of key cellular processes. Using a combined computational and experimental approach, we identify and characterize the elements that determine the recognitions between MP and their cognate ligands, between MP and their coupled proteins, and between MP and lipid environment. The integrated findings allow us to rationally develop small-molecule compounds for novel drug discovery.

Computational Chemistry and Molecular Biophysics Unit Staff

Computational Chemistry and Molecular Biophysics Unit Staff

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Computational Chemistry and Molecular Biophysics

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  • Careers at NIDA IRP
  • Accessibility
  • Privacy
  • HHS Vulnerability Disclosure
  • Freedom of Information Act
  • Document Viewing Tools
  • Offsite Links

  • Home
  • News
    ▼
    • Featured Paper of the Month
    • Reviews to Read
    • Hot off the Press
    • IRP News
    • Awards
    • Technology Development Initiative Paper of the Month
    • Seminar Series
    • Addiction Grand Rounds
  • About
    ▼
    • About NIDA IRP
    • Contact Us
    • Directions and Map
    • Careers at NIDA IRP
    • Emergency Contacts
    • Employee Assistance Resources
  • Organization
    ▼
    • Faculty
    • Office of the Scientific Director
    • Office of the Clinical Director
    • Office of Education and Career Development
    • Administrative Management Branch
    • Molecular Targets and Medications Discovery Branch
    • Cellular and Neurocomputational Systems Branch
    • Molecular Neuropsychiatry Research Branch
    • Neuroimaging Research Branch
    • Behavioral Neuroscience Research Branch
    • Integrative Neuroscience Research Branch
    • Translational Addiction Medicine Branch
    • Core Facilities
    • Community Outreach Group
  • Training Programs
    ▼
    • Office of Education and Career Development
    • OECD Awards
    • Summer Internship Program
    • Postbaccalaureate Program
    • Graduate Partnership Program
    • Postdoctoral Program
    • NIDA Speakers Bureau
    • Clinical Electives Program
    • Clinical Mentoring Program
  • Study Volunteers