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Volitional social interaction prevents drug addiction in rat models.

Nature Neuroscience Cover - November 2018

Hot Off the Press – November 19, 2018.

A new study published in Nature Neuroscience finds that social interactions can have a profound effect on behaviors related to addiction, and on the brain’s response to drug-associated cues. These findings have implications for people with substance use disorders (SUDs), because it suggests that social interaction can change the activity of specific neuronal circuits that control drug craving and relapse. The research was funded by the National Institutes of Health and led by Dr. Marco Venniro  from the Intramural Research Program of the National Institute on Drug Abuse (Dr. Yavin Shaham’s lab).

Publication Information

Venniro, Marco; Zhang, Michelle; Caprioli, Daniele; Hoots, Jennifer K; Golden, Sam A; Heins, Conor; Morales, Marisela; Epstein, David H; Shaham, Yavin

Volitional social interaction prevents drug addiction in rat models. Journal Article

In: Nat Neurosci, vol. 21, no. 11, pp. 1520–1529, 2018, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).

Abstract | Links

@article{Venniro:2018aab,
title = {Volitional social interaction prevents drug addiction in rat models.},
author = {Marco Venniro and Michelle Zhang and Daniele Caprioli and Jennifer K Hoots and Sam A Golden and Conor Heins and Marisela Morales and David H Epstein and Yavin Shaham},
url = {https://www.ncbi.nlm.nih.gov/pubmed/30323276},
doi = {10.1038/s41593-018-0246-6},
issn = {1546-1726 (Electronic); 1097-6256 (Linking)},
year = {2018},
date = {2018-11-01},
urldate = {2018-11-01},
journal = {Nat Neurosci},
volume = {21},
number = {11},
pages = {1520--1529},
address = {Intramural Research Program, NIDA, NIH, Baltimore, MD, USA. venniro.marco@nih.gov.},
abstract = {Addiction treatment has not been appreciably improved by neuroscientific research. One problem is that mechanistic studies using rodent models do not incorporate volitional social factors, which play a critical role in human addiction. Here, using rats, we introduce an operant model of choice between drugs and social interaction. Independent of sex, drug class, drug dose, training conditions, abstinence duration, social housing, or addiction score in Diagnostic & Statistical Manual IV-based and intermittent access models, operant social reward prevented drug self-administration. This protection was lessened by delay or punishment of the social reward but neither measure was correlated with the addiction score. Social-choice-induced abstinence also prevented incubation of methamphetamine craving. This protective effect was associated with activation of central amygdala PKCdelta-expressing inhibitory neurons and inhibition of anterior insular cortex activity. These findings highlight the need for incorporating social factors into neuroscience-based addiction research and support the wider implantation of socially based addiction treatments.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

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Addiction treatment has not been appreciably improved by neuroscientific research. One problem is that mechanistic studies using rodent models do not incorporate volitional social factors, which play a critical role in human addiction. Here, using rats, we introduce an operant model of choice between drugs and social interaction. Independent of sex, drug class, drug dose, training conditions, abstinence duration, social housing, or addiction score in Diagnostic & Statistical Manual IV-based and intermittent access models, operant social reward prevented drug self-administration. This protection was lessened by delay or punishment of the social reward but neither measure was correlated with the addiction score. Social-choice-induced abstinence also prevented incubation of methamphetamine craving. This protective effect was associated with activation of central amygdala PKCdelta-expressing inhibitory neurons and inhibition of anterior insular cortex activity. These findings highlight the need for incorporating social factors into neuroscience-based addiction research and support the wider implantation of socially based addiction treatments.

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  • https://www.ncbi.nlm.nih.gov/pubmed/30323276
  • doi:10.1038/s41593-018-0246-6

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