Hot Off the Press – May 18, 2023
NIDA researchers previously showed a role of Pir in fentanyl relapse after food choice-induced voluntary abstinence in rats, a procedure mimicking human abstinence or a significant reduction in drug self-administration because of the availability of alternative nondrug rewards. Here, they aimed to further characterize the role of Pir in fentanyl relapse by investigating the role of Pir afferent projections and analyzing molecular changes in relapse-activated Pir neurons. They identified dissociable roles of two Pir afferent projections (AI→Pir and PL→Pir) in relapse to fentanyl seeking versus reacquisition of fentanyl self-administration after voluntary abstinence. They also characterized molecular changes within Pir Fos-expressing neurons associated with fentanyl relapse.
In: J Neurosci, vol. 43, no. 14, pp. 2597–2614, 2023, ISSN: 1529-2401.