Hot Off the Press – January 26, 2023
We recently introduced a rat model of incubation (time-dependent increase) of oxycodone craving after voluntary abstinence induced by negative consequences of drug seeking. Here, we used the activity marker Fos, muscimol-baclofen (GABAa+GABAb receptor agonists) global inactivation, and Daun02 selective inactivation of putative relapse-associated neuronal ensembles, to demonstrate a key role of vSub neuronal ensembles in incubation of oxycodone craving after voluntary abstinence but not homecage forced abstinence. We also used a longitudinal functional MRI method and showed that functional connectivity changes in vSub-related circuits predict opioid relapse after abstinence induced by adverse consequences of opioid seeking.
Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier-induced voluntary abstinence Journal Article
In: Sci Adv, vol. 9, no. 2, pp. eadd8687, 2023, ISSN: 2375-2548.