Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier-induced voluntary abstinence

@article{pmid36630511,

title = {Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier-induced voluntary abstinence},

author = {Ida Fredriksson and Pei-Jung Tsai and Aniruddha Shekara and Ying Duan and Sarah V Applebey and Angelica Minier-Toribio and Ashley Batista and Jonathan J Chow and Lindsay Altidor and Estelle Barbier and Carlo Cifani and Xuan Li and David J Reiner and F Javier Rubio and Bruce T Hope and Yihong Yang and Jennifer M Bossert and Yavin Shaham},

url = {https://pubmed.ncbi.nlm.nih.gov/36630511/},

doi = {10.1126/sciadv.add8687},

issn = {2375-2548},

year  = {2023},

date = {2023-01-01},

urldate = {2023-01-01},

journal = {Sci Adv},

volume = {9},

number = {2},

pages = {eadd8687},

abstract = {High relapse rate is a key feature of opioid addiction. In humans, abstinence is often voluntary due to negative consequences of opioid seeking. To mimic this human condition, we recently introduced a rat model of incubation of oxycodone craving after electric barrier-induced voluntary abstinence. Incubation of drug craving refers to time-dependent increases in drug seeking after cessation of drug self-administration. Here, we used the activity marker Fos, muscimol-baclofen (GABAa + GABAb receptor agonists) global inactivation, Daun02-selective inactivation of putative relapse-associated neuronal ensembles, and fluorescence-activated cell sorting of Fos-positive cells and quantitative polymerase chain reaction to demonstrate a key role of vSub neuronal ensembles in incubation of oxycodone craving after voluntary abstinence, but not homecage forced abstinence. We also used a longitudinal functional magnetic resonance imaging method and showed that functional connectivity changes in vSub-related circuits predict opioid relapse after abstinence induced by adverse consequences of opioid seeking.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}