Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor.

@article{Yano:2018aa,

title = {Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor.},

author = {Hideaki Yano and Ning-Sheng Cai and Min Xu and Ravi Kumar Verma and William Rea and Alexander F Hoffman and Lei Shi and Jonathan A Javitch and Antonello Bonci and Sergi Ferre},

url = {https://www.ncbi.nlm.nih.gov/pubmed/29402888},

doi = {10.1038/s41467-017-02606-w},

issn = {2041-1723 (Electronic); 2041-1723 (Linking)},

year  = {2018},

date = {2018-02-05},

journal = {Nat Commun},

volume = {9},

number = {1},

pages = {486},

address = {National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA. hideaki.yano@nih.gov.},

abstract = {The two highly homologous subtypes of stimulatory G proteins Galphas (Gs) and Galphaolf (Golf) display contrasting expression patterns in the brain. Golf is predominant in the striatum, while Gs is predominant in the cortex. Yet, little is known about their functional distinctions. The dopamine D1 receptor (D1R) couples to Gs/olf and is highly expressed in cortical and striatal areas, making it an important therapeutic target for neuropsychiatric disorders. Using novel drug screening methods that allow analysis of specific G-protein subtype coupling, we found that, relative to dopamine, dihydrexidine and N-propyl-apomorphine behave as full D1R agonists when coupled to Gs, but as partial D1R agonists when coupled to Golf. The Gs/Golf-dependent biased agonism by dihydrexidine was consistently observed at the levels of cellular signaling, neuronal function, and behavior. Our findings of Gs/Golf-dependent functional selectivity in D1R ligands open a new avenue for the treatment of cortex-specific or striatum-specific neuropsychiatric dysfunction.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}