Hot Off the Press! – April 2015
Wang, Dong V; Yau, Hau-Jie; Broker, Carl J; Tsou, Jen-Hui; Bonci, Antonello; Ikemoto, Satoshi
Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation. Journal Article
In: Nat Neurosci, vol. 18, no. 5, pp. 728–735, 2015, ISSN: 1546-1726 (Electronic); 1097-6256 (Linking).
@article{Wang2015,
title = {Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation.},
author = {Dong V Wang and Hau-Jie Yau and Carl J Broker and Jen-Hui Tsou and Antonello Bonci and Satoshi Ikemoto},
url = {https://www.ncbi.nlm.nih.gov/pubmed/25867120},
doi = {10.1038/nn.3998},
issn = {1546-1726 (Electronic); 1097-6256 (Linking)},
year = {2015},
date = {2015-05-01},
urldate = {2015-05-01},
journal = {Nat Neurosci},
volume = {18},
number = {5},
pages = {728--735},
address = {Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.},
abstract = {Sharp wave-associated field oscillations ( approximately 200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal ripple activity and memory consolidation. We performed in vivo simultaneous recording in the MnR and hippocampus of mice and found that, when a group of MnR neurons was active, ripples were absent. Consistently, optogenetic stimulation of MnR neurons suppressed ripple activity and inhibition of these neurons increased ripple activity. Notably, using a fear conditioning procedure, we found that photostimulation of MnR neurons interfered with memory consolidation. Our results demonstrate a critical role of the MnR in regulating ripples and memory consolidation.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sharp wave-associated field oscillations ( approximately 200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal ripple activity and memory consolidation. We performed in vivo simultaneous recording in the MnR and hippocampus of mice and found that, when a group of MnR neurons was active, ripples were absent. Consistently, optogenetic stimulation of MnR neurons suppressed ripple activity and inhibition of these neurons increased ripple activity. Notably, using a fear conditioning procedure, we found that photostimulation of MnR neurons interfered with memory consolidation. Our results demonstrate a critical role of the MnR in regulating ripples and memory consolidation.
