Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.

@article{Yang:2017aa,

title = {Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.},

author = {Hong-Ju Yang and Hai-Ying Zhang and Guo-Hua Bi and Yi He and Jun-Tao Gao and Zheng-Xiong Xi},

url = {https://www.ncbi.nlm.nih.gov/pubmed/28700935},

doi = {10.1016/j.celrep.2017.06.046},

issn = {2211-1247 (Electronic)},

year  = {2017},

date = {2017-07-11},

urldate = {2017-07-11},

journal = {Cell Rep},

volume = {20},

number = {2},

pages = {319--332},

address = {Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA.},

abstract = {Cocaine users show reduced expression of the metabotropic glutamate receptor (mGluR2), but it is not clear whether this is a predisposing trait for addiction or a consequence of drug exposure. In this study, we found that a nonsense mutation at the mGluR2 gene decreased mGluR2 expression and altered the seeking and taking of cocaine. mGluR2 mutant rats show reduced sensitivity to cocaine reward, requiring more cocaine to reach satiation when it was freely available and ceasing their drug-seeking behavior sooner than controls when the response requirement was increased. mGluR2 mutant rats also show a lower propensity to relapse after a period of cocaine abstinence, an effect associated with reduced cocaine-induced dopamine and glutamate overflow in the nucleus accumbens. These findings suggest that mGluR2 polymorphisms or reduced availability of mGluR2 might be risk factors for the initial development of cocaine use but could actually protect against addiction by reducing sensitivity to cocaine reward.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}