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Delta Rhythm Orchestrates the Neural Activity Underlying the Resting State BOLD Signal via Phase–amplitude Coupling.

Featured Paper of the Month – June 2018
Published in Cerebral Cortex by Jaime, Saul; Gu, Hong; Sadacca, Brian F; Stein, Elliot A; Cavazos, Jose E; Yang, Yihong; Lu, Hanbing

Our brains always work, consciously or unconsciously. Functional connectivity MRI has identified so-called resting state brain networks (e.g. default mode network). Aberrant activity in such networks is implicated in neurological and psychiatric disorders. This work applies simultaneous electrophysiological recording and functional MRI to investigate the neurophysiological basis of the network activity…

The Coffeehouse: Art of Recovery

The NIDA Eliminating Stigma Team held its first coffeehouse event on Thursday May 10th, titled “The Coffeehouse: Art of Recovery.” The audience experienced powerful stories of struggle and triumph over mental illness and drug addiction through performances and presentations of poetry, spoken word, visual art, photography, and music. The event turned the atrium into a… [Read More]

The Coffeehouse: Art of Recovery

Join the NIDA IRP for an Eliminating Stigma Series event. Experience stories of struggle and triumph over addiction and mental illness through spoken word, art, and music. Coffee and light refreshments will be served. May 10, 1:00 pm – 2:30 pm in the Biomedical Research Center Atrium.

Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature.

Featured Paper of the Month – May 2018
Published in Neuropsychopharmacology by Solis, Ernesto Jr; Cameron-Burr, Keaton T; Shaham, Yavin; Kiyatkin, Eugene A

Fentanyl is a potent synthetic opioid used clinically to treat pain and as a general anesthetic. Recently, fentanyl has emerged as a recreational drug and its overdose has been linked to numerous deaths in the US. To better understand how fentanyl affects the brain, we used electrochemical techniques in rats and examined the effect of intravenous fentanyl on oxygen and glucose levels in the nucleus accumbens, a brain region implicated in reward and addiction…

Yihong Yang inducted as a Fellow of the American Institute for Medical and Biological Engineering

The American Institute for Medical and Biological Engineering (AIMBE) has announced the induction of Yihong Yang, Ph.D., Senior Investigator and Chief of the Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Drug Abuse, National Institutes of Health to its College of Fellows. Dr. Yang was nominated, reviewed, and elected by peers and members of… [Read More]

Discovery and development of varenicline for smoking cessation

Reviews To Read – April 3, 2018. from the Addiction Biology Unit Quitting smoking is challenging. The recent development of varenicline (Chantix®) for smoking cessation is a successful story. In this article, we review the strong theoretical rationale, major findings in preclinical and clinical studies with varenicline, and post-market surveillance. We also discuss current major… [Read More]

Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission.

Featured Paper of the Month – April 2018
Published in Cell Reports by Barker, David J; Miranda-Barrientos, Jorge; Zhang, Shiliang; Root, David H; Wang, Hui-Ling; Liu, Bing; Calipari, Erin S; Morales, Marisela

The lateral habenula (LHb) is a brain structure that participates in cognitive and emotional processing and has been implicated in several mental disorders. Although one of the largest inputs to the LHb originates in the lateral preoptic area (LPO), little is known about how the LPO participates in the regulation of LHb function. In their recent study, Barker and colleagues provide evidence that the LPO exerts bivalent control over the LHb through the convergent transmission of excitatory LPO glutamate and inhibitory LPO g-aminobutyric acid (GABA) onto single LHb neurons…

2018 NIDA IRP Women Scientist Advisors Awards

The NIDA IRP Women Scientist Advisors awards ceremony is held annually to recognize the accomplishments of outstanding women scientists. The 2018 awardees are: Elisabeth de Castro Caparelli – Staff Scientist Melissa Sharpe – Postdoctoral Fellow Congratulations to this year’s winners! Click here to learn more about the Woman Scientist Advisors (WSA) and see previous winners.

NIDA IRP presents awards at the 2018 Baltimore Science Fair

The Baltimore Science Fair was held this past weekend at Towson University. Over 100 middle school and high school students from Baltimore City, Baltimore, Carrol, Cecil, Harford, and Howard Counties participated, spending many hours on Saturday describing their work to a LOT of judges. Judges came from all over, including FDA, other NIH institutes, US… [Read More]

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

Hot Off the Press – March 28, 2018. Scientists at the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) have uncovered evidence that shows a more complex and elaborate role for the body’s hard-working G protein-coupled receptors (GPCRs) than previously thought, suggesting a conceptual advance in the fields of biochemistry and pharmacology. With… [Read More]