Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature.

Featured Paper of the Month – June 2018.

Our brains always work, consciously or unconsciously. Functional connectivity MRI has identified so-called resting state brain networks (e.g. default mode network). Aberrant activity in such networks is implicated in neurological and psychiatric disorders. This work applies simultaneous electrophysiological recording and functional MRI to investigate the neurophysiological basis of the network activity.

Publication Information

Jaime, Saul; Gu, Hong; Sadacca, Brian F; Stein, Elliot A; Cavazos, Jose E; Yang, Yihong; Lu, Hanbing

Delta Rhythm Orchestrates the Neural Activity Underlying the Resting State BOLD Signal via Phase-amplitude Coupling. Journal Article

In: Cereb Cortex, pp. 1–15, 2019, ISSN: 1460-2199 (Electronic); 1047-3211 (Linking).

Abstract | Links

@article{Jaime:2017aa,

title = {Delta Rhythm Orchestrates the Neural Activity Underlying the Resting State BOLD Signal via Phase-amplitude Coupling.},

author = {Saul Jaime and Hong Gu and Brian F Sadacca and Elliot A Stein and Jose E Cavazos and Yihong Yang and Hanbing Lu},

url = {https://www.ncbi.nlm.nih.gov/pubmed/29161352},

doi = {10.1093/cercor/bhx310},

issn = {1460-2199 (Electronic); 1047-3211 (Linking)},

year  = {2019},

date = {2019-01-01},

journal = {Cereb Cortex},

pages = {1--15},

address = {Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, USA.},

abstract = {Spontaneous ongoing neuronal activity is a prominent feature of the mammalian brain. Temporal and spatial patterns of such ongoing activity have been exploited to examine large-scale brain network organization and function. However, the neurophysiological basis of this spontaneous brain activity as detected by resting-state functional Magnetic Resonance Imaging (fMRI) remains poorly understood. To this end, multi-site local field potentials (LFP) and blood oxygenation level-dependent (BOLD) fMRI were simultaneously recorded in the rat striatum along with local pharmacological manipulation of striatal activity. Results demonstrate that delta (delta) band LFP power negatively, while beta (beta) and gamma (gamma) band LFPs positively correlated with BOLD fluctuation. Furthermore, there was strong cross-frequency phase-amplitude coupling (PAC), with the phase of delta LFPs significantly modulating the amplitude of the high frequency signal. Enhancing dopaminergic neuronal activity significantly reduced ventral striatal functional connectivity, delta LFP-BOLD correlation, and the PAC effect. These data suggest that different frequency bands of the LFP contribute distinctively to BOLD spontaneous fluctuation and that PAC is the organizing mechanism through which low frequency LFPs orchestrate neural activity that underlies resting state functional connectivity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}