Relapse after electric barrier-induced voluntary abstinence: A review

@article{pmid38508102,

title = {Relapse after electric barrier-induced voluntary abstinence: A review},

author = {Kenichiro Negishi and Ida Fredriksson and Jennifer M Bossert and Abraham Zangen and Yavin Shaham},

url = {https://pubmed.ncbi.nlm.nih.gov/38508102/},

doi = {10.1016/j.conb.2024.102856},

issn = {1873-6882},

year  = {2024},

date = {2024-03-01},

urldate = {2024-03-01},

journal = {Curr Opin Neurobiol},

volume = {86},

pages = {102856},

abstract = {Relapse to drug use during abstinence is a defining feature of addiction. To date, however, results from studies using rat relapse/reinstatement models have yet to result in FDA-approved medications for relapse prevention. To address this translational gap, we and others have developed rat models of relapse after voluntary abstinence from drug self-administration. One of these models is the electric barrier conflict model. Here, we introduce the model, and then review studies on behavioral and neuropharmacological mechanisms of cue-induced relapse and incubation of drug seeking (time-dependent increase in drug seeking during abstinence) after electric barrier-induced abstinence. We also briefly discuss future directions and potential clinical implications. One major conclusion of our review is that the brain mechanisms controlling drug relapse after electrical barrier-induced voluntary abstinence are likely distinct from those controlling relapse after homecage forced abstinence.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}